Transporters in Drug Discovery and Development

Written By Yurong Lai
Transporters in Drug Discovery and Development
  • Publsiher : Woodhead Publishing
  • Release : 22 August 2014
  • ISBN : 190881828X
  • Pages : 780 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Transporters in Drug Discovery and Development written by Yurong Lai which was release on 22 August 2014, this book published by Woodhead Publishing. Available in PDF, EPUB and Kindle Format. Book excerpt: Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity

Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development
  • Author : Yurong Lai
  • Publisher : Woodhead Publishing
  • Release Date : 2014-08-22
  • Total pages : 780
  • ISBN : 190881828X
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Summary : Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant ...

Transporters in Drug Development

Transporters in Drug Development
  • Author : Yuichi Sugiyama,Bente Steffansen
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-09-16
  • Total pages : 317
  • ISBN : 190881828X
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Summary : Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization ...

Drug Transporters

Drug Transporters
  • Author : Guofeng You,Marilyn E. Morris
  • Publisher : John Wiley & Sons
  • Release Date : 2014-07-07
  • Total pages : 528
  • ISBN : 190881828X
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Summary : This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. • Describes drug transporter families, mechanisms, and clinical ...

Drug Transporters

Drug Transporters
  • Author : Glynis Nicholls,Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-12-31
  • Total pages : 477
  • ISBN : 190881828X
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Summary : Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second ...

Membrane Transporters in Drug Discovery and Development

Membrane Transporters in Drug Discovery and Development
  • Author : Qing Yan
  • Publisher : Humana
  • Release Date : 2010-04-26
  • Total pages : 365
  • ISBN : 190881828X
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Summary : This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development....

Oral Bioavailability Assessment

Oral Bioavailability Assessment
  • Author : Ayman F. El-Kattan
  • Publisher : John Wiley & Sons
  • Release Date : 2017-06-06
  • Total pages : 448
  • ISBN : 190881828X
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Summary : Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the ...

Drug Transporters

Drug Transporters
  • Author : Glynis Nicholls,Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016
  • Total pages : 870
  • ISBN : 190881828X
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Summary : Download or read online Drug Transporters written by Glynis Nicholls,Kuresh Youdim, published by Royal Society of Chemistry which was released on 2016. Get Drug Transporters Books now! Available in PDF, ePub and Kindle....

Drug Transporters Volume 2

Drug Transporters Volume 2
  • Author : Dr Glynis Nicholls ,Dr Kuresh Youdim
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-08-10
  • Total pages : 270
  • ISBN : 190881828X
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Summary : Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis ...

Pharmacogenomics of Human Drug Transporters

Pharmacogenomics of Human Drug Transporters
  • Author : Toshihisa Ishikawa,Richard B. Kim,Jörg König
  • Publisher : John Wiley & Sons
  • Release Date : 2013-03-11
  • Total pages : 440
  • ISBN : 190881828X
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Summary : Sets the foundation for safer, more effective drugtherapies With this book as their guide, readers will discover how toapply our current understanding of the pharmacogenomics of drugtransporters to advance their own drug discovery and developmentefforts. In particular, the book explains how new findings in thefield now enable researchers to more ...

ADME Enabling Technologies in Drug Design and Development

ADME Enabling Technologies in Drug Design and Development
  • Author : Donglu Zhang,Sekhar Surapaneni
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-13
  • Total pages : 800
  • ISBN : 190881828X
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Summary : A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the developmentof analytical techniques such as mass spectrometry and molecularbiology tools, resulting in important advances in drug discovery,particularly in the area of absorption, distribution, metabolism,and excretion (ADME). ADME-Enabling Technologies in Drug ...

Evaluation of Drug Candidates for Preclinical Development

Evaluation of Drug Candidates for Preclinical Development
  • Author : Chao Han,Charles B. Davis,Binghe Wang
  • Publisher : John Wiley & Sons
  • Release Date : 2010-01-06
  • Total pages : 304
  • ISBN : 190881828X
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Summary : Emphasizes the integration of major areas of drug discovery and their importance in candidate evaluation It is believed that selecting the "right" drug candidate for development is the key to success. In the last decade, pharmaceutical R&D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early ...

Drug Metabolism and Pharmacokinetics Quick Guide

Drug Metabolism and Pharmacokinetics Quick Guide
  • Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-07
  • Total pages : 214
  • ISBN : 190881828X
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Summary : Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. ...

Oral Bioavailability

Oral Bioavailability
  • Author : Xiaoling Li
  • Publisher : John Wiley & Sons
  • Release Date : 2011-08-04
  • Total pages : 560
  • ISBN : 190881828X
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Summary : Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, ...

Enzyme Inhibition in Drug Discovery and Development

Enzyme Inhibition in Drug Discovery and Development
  • Author : Chuang Lu,Albert P. Li
  • Publisher : John Wiley & Sons
  • Release Date : 2010-01-26
  • Total pages : 868
  • ISBN : 190881828X
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Summary : The science and applied approaches of enzyme inhibition in drug discovery and development Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, Enzyme Inhibition in Drug Discovery and Development examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug ...

Membrane Transporters

Membrane Transporters
  • Author : Qing Yan
  • Publisher : Humana Press
  • Release Date : 2010-10-28
  • Total pages : 372
  • ISBN : 190881828X
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Summary : Studies of membrane transporters have had great impact on our und- standing human diseases and the design of effective drugs. About 30% of current clinically marketed drugs are targeting membrane transporters or channels. Membrane Transporters: Methods and Protocols provides various practical methodologies for the ongoing research on membrane transporters. To provide ...