Trace Amines and Neurological Disorders

Written By Tahira Farooqui
Trace Amines and Neurological Disorders
  • Publsiher : Academic Press
  • Release : 12 July 2016
  • ISBN : 0128036168
  • Pages : 432 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Trace Amines and Neurological Disorders written by Tahira Farooqui which was release on 12 July 2016, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Trace Amines and Neurological Disorders

Trace Amines and Neurological Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2016-07-12
  • Total pages : 432
  • ISBN : 0128036168
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Summary : Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating ...

Neuropsychopharmacology of the Trace Amines

Neuropsychopharmacology of the Trace Amines
  • Author : Alan A. Boulton,Peter R. Bieck,L. Maitre,P. Riederer
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 510
  • ISBN : 0128036168
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Summary : A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed. Techniques for quantitative analyses included radioenzymatic procedures and, more recently, HPlC-EC and auto mated GC-MS. The methods are applied after separation of the sub stances to be analyzed ...

Encyclopedia of Psychopharmacology

Encyclopedia of Psychopharmacology
  • Author : Ian Stolerman
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-07-31
  • Total pages : 1392
  • ISBN : 0128036168
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Summary : Here is a broad overview of the central topics and issues in psychopharmacology, biological psychiatry and behavioral neurosciences, with information about developments in the field, including novel drugs and technologies. The more than 2000 entries are written by leading experts in pharmacology and psychiatry and comprise in-depth essays, illustrated with full-color ...

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2020-03-20
  • Total pages : 498
  • ISBN : 0128036168
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Summary : Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders provides an overview on the risk factors for insulin resistance in visceral and neurological disorders. The book focuses on molecular mechanisms and signal transduction processes associated with the links. The comprehensive information in this monograph will not only help ...

Molecular Aspects of Neurodegeneration Neuroprotection and Regeneration in Neurological Disorders

Molecular Aspects of Neurodegeneration  Neuroprotection  and Regeneration in Neurological Disorders
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2020-09-07
  • Total pages : 400
  • ISBN : 0128036168
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Summary : Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also ...

Encyclopedia of Neuroscience Volume 1

Encyclopedia of Neuroscience  Volume 1
  • Author : Larry R. Squire
  • Publisher : Academic Press
  • Release Date : 2009-06-12
  • Total pages : 12505
  • ISBN : 0128036168
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Summary : The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before ...

Research Methods in Neurochemistry

Research Methods in Neurochemistry
  • Author : Neville Marks
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 442
  • ISBN : 0128036168
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Summary : The fourth volume of Research Methods in Neurochemistry includes chapters on different aspects of topics touched on in previous volumes and develops a number of new themes as well. The bias, though not entirely intended, is directed toward studies of macromolecules, both at the meta bolic level in relation to ...

Neuroinflammation Resolution and Neuroprotection in the Brain

Neuroinflammation  Resolution  and Neuroprotection in the Brain
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2021-10-01
  • Total pages : 332
  • ISBN : 0128036168
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Summary : Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative ...

The Neuroscience of Cocaine

The Neuroscience of Cocaine
  • Author : Victor R. Preedy
  • Publisher : Academic Press
  • Release Date : 2017-05-23
  • Total pages : 774
  • ISBN : 0128036168
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Summary : The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in ...

Neurochemical Aspects of Alzheimer s Disease

Neurochemical Aspects of Alzheimer s Disease
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2017-05-25
  • Total pages : 414
  • ISBN : 0128036168
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Summary : Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may ...

Addiction Medicine E Book

Addiction Medicine E Book
  • Author : Bankole Johnson
  • Publisher : Elsevier Health Sciences
  • Release Date : 2019-12-12
  • Total pages : 788
  • ISBN : 0128036168
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Summary : Integrating scientific knowledge with today’s most effective treatment options, Addiction Medicine: Science and Practice, 2nd Edition, provides a wealth of information on addictions to substances and behavioral addictions. It discusses the concrete research on how the brain and body are affected by addictions, improving your understanding of how patients ...

Neurobiology of the Trace Amines

Neurobiology of the Trace Amines
  • Author : Alan A. Boulton,Glen B. Baker,William G. Dewhurst,Merton Sandler
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-12
  • Total pages : 598
  • ISBN : 0128036168
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Summary : Many of the trace amines-more correctly called biogenic amines have been known for decades, but because of their tiny concentra tions (0. 01-100 ng/g) in brain, it was only after the development of sophisticated analytical techniques (such as mass spectrometry) that they could be identified and quantitated in nervous tissue. ...

Chemical and Cellular Architecture

Chemical and Cellular Architecture
  • Author : Abel Lajtha
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-18
  • Total pages : 496
  • ISBN : 0128036168
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Summary : After the completion of the first edition of this series, this editor thought that a new edition would not be warranted in less than IS, perhaps 20, years, but it seems that we live in a time in which rapid changes are the norm and findings in a field such as ...

Ischemic and Traumatic Brain and Spinal Cord Injuries

Ischemic and Traumatic Brain and Spinal Cord Injuries
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2018-03-21
  • Total pages : 484
  • ISBN : 0128036168
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Summary : Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting-edge information on molecular mechanisms, including the signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs ...

Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2019-04-15
  • Total pages : 386
  • ISBN : 0128036168
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Summary : Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of ...