The Organic Chemistry of Drug Design and Drug Action

Written By Richard B. Silverman
The Organic Chemistry of Drug Design and Drug Action
  • Publsiher : Academic Press
  • Release : 29 March 2014
  • ISBN : 0123820316
  • Pages : 536 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman which was release on 29 March 2014, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Richard B. Silverman,Mark W. Holladay
  • Publisher : Academic Press
  • Release Date : 2014-03-29
  • Total pages : 536
  • ISBN : 0123820316
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Summary : The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new ...

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Richard B. Silverman
  • Publisher : Academic Press
  • Release Date : 2005-01-19
  • Total pages : 212
  • ISBN : 0123820316
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Summary : This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The ...

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Sam Springer
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 0123820316
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Summary : Download or read online The Organic Chemistry of Drug Design and Drug Action written by Sam Springer, published by which was released on 2018. Get The Organic Chemistry of Drug Design and Drug Action Books now! Available in PDF, ePub and Kindle....

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action
  • Author : Richard B. Silverman
  • Publisher : Elsevier
  • Release Date : 2012-12-02
  • Total pages : 617
  • ISBN : 0123820316
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Summary : Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug ...

The Organic Chemistry Of Drug Design And Drug Action 2E

The Organic Chemistry Of Drug Design And Drug Action  2E
  • Author : R. B. Silverman
  • Publisher : Unknown
  • Release Date : 2004-01-01
  • Total pages : 617
  • ISBN : 0123820316
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Summary : Drug discovery, design and development. Receptors. Enzymes. Enzyme inhibition and inactivation. DNA-interactive agents. Drug metabolism. Prodrugs and drug delivery systems....

The Organic Chemistry of Drug Design and Drug Action Power PDF

The Organic Chemistry of Drug Design and Drug Action  Power PDF
  • Author : Richard B. Silverman
  • Publisher : Elsevier
  • Release Date : 2005-02-04
  • Total pages : 1275
  • ISBN : 0123820316
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Summary : This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The ...

Organic Chemistry of Enzyme Catalyzed Reactions Revised Edition

Organic Chemistry of Enzyme Catalyzed Reactions  Revised Edition
  • Author : Richard B. Silverman
  • Publisher : Elsevier
  • Release Date : 2002-03-07
  • Total pages : 800
  • ISBN : 0123820316
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Summary : The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is ...

Pharmacology

Pharmacology
  • Author : Miles Hacker,William S. Messer,Kenneth A. Bachmann
  • Publisher : Academic Press
  • Release Date : 2009-06-19
  • Total pages : 608
  • ISBN : 0123820316
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Summary : Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of ...

An Introduction to Drug Design

An Introduction to Drug Design
  • Author : S. N. Pandeya,J. R. Dimmock
  • Publisher : New Age International
  • Release Date : 1997
  • Total pages : 214
  • ISBN : 0123820316
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Summary : The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To ...

Chemical Drug Design

Chemical Drug Design
  • Author : Girish Kumar Gupta,Vinod Kumar
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2016-10-10
  • Total pages : 297
  • ISBN : 0123820316
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Summary : Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs....

Strategies for Organic Drug Synthesis and Design

Strategies for Organic Drug Synthesis and Design
  • Author : Daniel Lednicer
  • Publisher : Wiley-Interscience
  • Release Date : 2009-03-04
  • Total pages : 650
  • ISBN : 0123820316
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Summary : This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced ...

Fundamentals of Medicinal Chemistry and Drug Metabolism

Fundamentals of Medicinal Chemistry and Drug Metabolism
  • Author : M. O. Faruk Khan,Ashok Philip
  • Publisher : Bentham Science Publishers
  • Release Date : 2018-06-01
  • Total pages : 350
  • ISBN : 0123820316
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Summary : The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical basis of drug action. This first volume of the series is comprised of 8 chapters focusing on basic ...

Drug Design and Action

Drug Design and Action
  • Author : Joaquín M. Campos Rosa,M. Encarnación Camacho Quesada
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2017-08-21
  • Total pages : 186
  • ISBN : 0123820316
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Summary : This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug ...

Managing the Drug Discovery Process

Managing the Drug Discovery Process
  • Author : Walter Moos,Susan Miller,Stephen Munk,Barbara Munk
  • Publisher : Woodhead Publishing
  • Release Date : 2016-11-08
  • Total pages : 536
  • ISBN : 0123820316
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Summary : Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, ...

Foye s Principles of Medicinal Chemistry

Foye s Principles of Medicinal Chemistry
  • Author : Thomas L. Lemke,David A. Williams
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2008
  • Total pages : 1406
  • ISBN : 0123820316
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Summary : The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options ...