Target Discovery and Validation

Written By Alleyn T. Plowright
Target Discovery and Validation
  • Publsiher : John Wiley & Sons
  • Release : 31 December 2019
  • ISBN : 3527345299
  • Pages : 400 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Target Discovery and Validation written by Alleyn T. Plowright which was release on 31 December 2019, this book published by John Wiley & Sons. Available in PDF, EPUB and Kindle Format. Book excerpt: The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Target Discovery and Validation

Target Discovery and Validation
  • Author : Alleyn T. Plowright
  • Publisher : John Wiley & Sons
  • Release Date : 2019-12-31
  • Total pages : 400
  • ISBN : 3527345299
GET BOOK

Summary : The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses ...

Target Validation in Drug Discovery

Target Validation in Drug Discovery
  • Author : Brian W. Metcalf,Susan Dillon
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Total pages : 296
  • ISBN : 3527345299
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Summary : This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases ...

Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery
  • Author : Jurgen Moll,Riccardo Colombo
  • Publisher : Humana Press
  • Release Date : 2016-05-01
  • Total pages : 388
  • ISBN : 3527345299
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Summary : This Methods in Molecular Biology book details current procedures for identifying and validating new drug targets. Includes methods and approaches covering biochemical, cell based, in vivo models and translational methods, as well as relevant case reports."...

High content Screening for Drug Discovery and Target Validation

High content Screening for Drug Discovery and Target Validation
  • Author : Shauna Farr-Jones
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 212
  • ISBN : 3527345299
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Summary : Download or read online High content Screening for Drug Discovery and Target Validation written by Shauna Farr-Jones, published by which was released on 2004. Get High content Screening for Drug Discovery and Target Validation Books now! Available in PDF, ePub and Kindle....

In Silico Technologies in Drug Target Identification and Validation

In Silico Technologies in Drug Target Identification and Validation
  • Author : Darryl Leon,Scott Markel
  • Publisher : CRC Press
  • Release Date : 2006-06-13
  • Total pages : 504
  • ISBN : 3527345299
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Summary : The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Identification and Validation ...

Imaging in Drug Discovery and Early Clinical Trials

Imaging in Drug Discovery and Early Clinical Trials
  • Author : Markus Rudin
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-07-11
  • Total pages : 392
  • ISBN : 3527345299
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Summary : This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging ...

Drug Target Selection and Validation

Drug Target Selection and Validation
  • Author : Marcus T. Scotti,Carolina L. Bellera
  • Publisher : Springer
  • Release Date : 2022-07-19
  • Total pages : 257
  • ISBN : 3527345299
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Summary : The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in ...

Drug Discovery

Drug Discovery
  • Author : Jie Jack Li,E. J. Corey
  • Publisher : John Wiley & Sons
  • Release Date : 2013-04-03
  • Total pages : 570
  • ISBN : 3527345299
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Summary : Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions ...

Deriving Drug Discovery Value from Large Scale Genetic Bioresources

Deriving Drug Discovery Value from Large Scale Genetic Bioresources
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Roundtable on Genomics and Precision Health
  • Publisher : National Academies Press
  • Release Date : 2016-12-02
  • Total pages : 114
  • ISBN : 3527345299
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Summary : The process of discovering and developing a new drug or therapy is extremely costly and time consuming, and recently, it has been estimated that the creation of a new medicine costs on average more than $2 billion and takes 10 years to reach patients. The challenges associated with bringing new medicines to ...

Handbook of Drug Screening Second Edition

Handbook of Drug Screening  Second Edition
  • Author : Ramakrishna Seethala,Litao Zhang
  • Publisher : CRC Press
  • Release Date : 2009-06-24
  • Total pages : 489
  • ISBN : 3527345299
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Summary : A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies....

Special Topics in Drug Discovery

Special Topics in Drug Discovery
  • Author : Taosheng Chen,Sergio Chai
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-11-30
  • Total pages : 190
  • ISBN : 3527345299
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Summary : Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered ...

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • Total pages : 594
  • ISBN : 3527345299
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Summary : This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on ...

Therapeutic Target Identification Validation and Drug Discovery for Traumatic Brain Injury

Therapeutic Target Identification  Validation and Drug Discovery for Traumatic Brain Injury
  • Author : Alexander Morin
  • Publisher : Unknown
  • Release Date : 2020
  • Total pages : 212
  • ISBN : 3527345299
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Summary : Download or read online Therapeutic Target Identification Validation and Drug Discovery for Traumatic Brain Injury written by Alexander Morin, published by which was released on 2020. Get Therapeutic Target Identification Validation and Drug Discovery for Traumatic Brain Injury Books now! Available in PDF, ePub and Kindle....

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : James Samanen
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 3527345299
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Summary : Successful drugs have a good return on investment by bringing in considerably more revenue than the expenses of discovery, development, and manufacturing. Successful drugs pay for all drug projects, those that fail and those that have yet to fail or succeed. Most research and development (R&D) projects fail. Since ...

Prostate Cancer

Prostate Cancer
  • Author : Philippe E. Spiess
  • Publisher : IntechOpen
  • Release Date : 2011-11-25
  • Total pages : 530
  • ISBN : 3527345299
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Summary : The present textbook highlights many of the exciting discoveries made in the diagnosis and treatment of prostate cancer over the past decade. International thought leaders have contributed to this effort providing a comprehensive and state-of-the art review of the signaling pathways and genetic alterations essential in prostate cancer. This work ...