Protein Homeostasis Second Edition

Written By Richard I. Morimoto
Protein Homeostasis  Second Edition
  • Publsiher : Perspectives Cshl
  • Release : 25 May 2022
  • ISBN : 9781621822967
  • Pages : 562 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Protein Homeostasis Second Edition written by Richard I. Morimoto which was release on 25 May 2022, this book published by Perspectives Cshl. Available in PDF, EPUB and Kindle Format. Book excerpt: The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity). Discussions of the responses by cells when errors in protein quality control occur, the medical disorders that can result (e.g., Alzheimer disease), and pharmacologic approaches to ameliorate protein conformational disorders are also included. This book is therefore an essential reference for biochemists, cell biologists, and all biomedical scientists wishing to understand the pathological consequences of and potential therapies for proteostasis deficiencies in common human diseases.

Protein Homeostasis Second Edition

Protein Homeostasis  Second Edition
  • Author : Richard I. Morimoto,Jeffery W. Kelly,F. Ulrich Hartl
  • Publisher : Perspectives Cshl
  • Release Date : 2019
  • Total pages : 562
  • ISBN : 9781621822967
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Summary : The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting ...

Protein Homeostasis Diseases

Protein Homeostasis Diseases
  • Author : Angel L. Pey
  • Publisher : Academic Press
  • Release Date : 2020-02-13
  • Total pages : 450
  • ISBN : 9781621822967
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Summary : Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components ...

Proteostasis and Disease

Proteostasis and Disease
  • Author : Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
  • Publisher : Springer
  • Release Date : 2020-06-01
  • Total pages : 345
  • ISBN : 9781621822967
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Summary : This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and ...

Impairment of Protein Homeostasis in Parkinson s Disease

Impairment of Protein Homeostasis in Parkinson s Disease
  • Author : Maike Lichtenberg
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 212
  • ISBN : 9781621822967
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Summary : Download or read online Impairment of Protein Homeostasis in Parkinson s Disease written by Maike Lichtenberg, published by which was released on 2011. Get Impairment of Protein Homeostasis in Parkinson s Disease Books now! Available in PDF, ePub and Kindle....

Chaperones Protein Homeostasis and Protein Aggregation Diseases

Chaperones  Protein Homeostasis and Protein Aggregation Diseases
  • Author : Harm Harmannus Kampinga
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 212
  • ISBN : 9781621822967
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Summary : Download or read online Chaperones Protein Homeostasis and Protein Aggregation Diseases written by Harm Harmannus Kampinga, published by which was released on 2014. Get Chaperones Protein Homeostasis and Protein Aggregation Diseases Books now! Available in PDF, ePub and Kindle....

Proteostasis and Chaperone Surveillance

Proteostasis and Chaperone Surveillance
  • Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar,Parvaiz Ahmad
  • Publisher : Springer
  • Release Date : 2015-11-26
  • Total pages : 180
  • ISBN : 9781621822967
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Summary : Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, ...

Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health Disease

Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health   Disease
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 230
  • ISBN : 9781621822967
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Summary : Download or read online Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health Disease written by , published by which was released on 2016. Get Abstracts of Papers Presented at the 2016 Meeting on Protein Homeostasis in Health Disease Books now! Available in PDF, ePub and Kindle....

Immunity Tumors and Aging The Role of HSP70

Immunity  Tumors and Aging  The Role of HSP70
  • Author : Igor Malyshev
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-01-08
  • Total pages : 141
  • ISBN : 9781621822967
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Summary : The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of ...

Finding Balance in Huntington s Disease

Finding Balance in Huntington s Disease
  • Author : Joseph Ochaba
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 254
  • ISBN : 9781621822967
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Summary : The disruption of protein quality control networks that ensure proper folding and degradation of cellular proteins is likely central to pathology in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and other "protein misfolding" diseases (La Spada and Taylor, 2010; Wilkinson et al., 2010). A detailed understanding of the proteostasis network ...

Heat Shock Factor

Heat Shock Factor
  • Author : Akira Nakai
  • Publisher : Springer
  • Release Date : 2016-01-06
  • Total pages : 301
  • ISBN : 9781621822967
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Summary : This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is ...

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones
  • Author : Gregory Lloyd Blatch,Adrienne Lesley Edkins
  • Publisher : Springer
  • Release Date : 2014-12-08
  • Total pages : 276
  • ISBN : 9781621822967
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Summary : Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client ...

Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases
  • Author : Richard I. Morimoto,Yves Christen
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-13
  • Total pages : 136
  • ISBN : 9781621822967
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Summary : The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of ...

A Role for Processing bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells

A Role for Processing bodies in the Maintenance of Protein Homeostasis in Eukaryotic Cells
  • Author : Qian Shi
  • Publisher : Unknown
  • Release Date : 2020
  • Total pages : 125
  • ISBN : 9781621822967
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Summary : The proper maintenance of protein homeostasis is critical for the normal physiology and survival of all cells. These functions are carried out by a large group of proteins that is collectively referred to as the protein quality control (PQC) system of cell. Under normal conditions, misfolded proteins are refolded, degraded, ...

Protein Metabolism and Homeostasis in Aging

Protein Metabolism and Homeostasis in Aging
  • Author : Nektarios Tavernarakis
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-01-11
  • Total pages : 249
  • ISBN : 9781621822967
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Summary : Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging ...

Parkinson s Disease New Insights for the Healthcare Professional 2013 Edition

Parkinson s Disease  New Insights for the Healthcare Professional  2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-07-22
  • Total pages : 778
  • ISBN : 9781621822967
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Summary : Parkinson’s Disease: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Parkinson’s Disease: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the ...