Piperidine Based Drug Discovery

Written By Ruben Vardanyan
Piperidine Based Drug Discovery
  • Publsiher : Elsevier
  • Release : 12 June 2017
  • ISBN : 0128134283
  • Pages : 358 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKPiperidine Based Drug Discovery


Read or download book entitled Piperidine Based Drug Discovery written by Ruben Vardanyan which was release on 12 June 2017, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Piperidine Based Drug Discovery

Piperidine Based Drug Discovery
  • Author : Ruben Vardanyan
  • Publisher : Elsevier
  • Release Date : 2017-06-12
  • Total pages : 358
  • ISBN : 0128134283
GET BOOK

Summary : Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related ...

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • Total pages : 560
  • ISBN : 0128134283
GET BOOK

Summary : A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that ...

Small molecule scaffold synthesis one bead one compound library synthesis and method development in drug discovery

Small molecule scaffold synthesis  one bead one compound library synthesis  and method development in drug discovery
  • Author : Seth M. Dixon
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 630
  • ISBN : 0128134283
GET BOOK

Summary : Download or read online Small molecule scaffold synthesis one bead one compound library synthesis and method development in drug discovery written by Seth M. Dixon, published by which was released on 2006. Get Small molecule scaffold synthesis one bead one compound library synthesis and method development in drug discovery Books now! ...

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery
  • Author : David C Blakemore,Paul M Doyle,Yvette M Fobian
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-07-15
  • Total pages : 517
  • ISBN : 0128134283
GET BOOK

Summary : Building on key reactions presented in Volume 1, Synthetic Methods in Drug Discovery Volume 2 covers a range of important reaction types including organometallic chemistry, fluorination approaches and asymmetric methods as well as new and exciting areas such as Csp2-Csp3 couplings, catalytic amide bond forming reactions, hydrogen borrowing chemistry and methods ...

Drug Discovery with Privileged Building Blocks

Drug Discovery with Privileged Building Blocks
  • Author : Jie Jack Li,Minmin Yang
  • Publisher : CRC Press
  • Release Date : 2021-10-21
  • Total pages : 320
  • ISBN : 0128134283
GET BOOK

Summary : Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of ...

Fragment based Drug Discovery

Fragment based Drug Discovery
  • Author : Daniel A. Erlanson,Wolfgang Jahnke,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-23
  • Total pages : 528
  • ISBN : 0128134283
GET BOOK

Summary : From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of ...

Peptide based Drug Discovery

Peptide based Drug Discovery
  • Author : Ved Srivastava
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-06-22
  • Total pages : 588
  • ISBN : 0128134283
GET BOOK

Summary : With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the ...

High Throughput Lead Optimization in Drug Discovery

High Throughput Lead Optimization in Drug Discovery
  • Author : Tushar Kshirsagar
  • Publisher : CRC Press
  • Release Date : 2008-03-04
  • Total pages : 256
  • ISBN : 0128134283
GET BOOK

Summary : A Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate ...

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
  • Author : Robert Stroud,Janet Finer-Moore
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • Total pages : 400
  • ISBN : 0128134283
GET BOOK

Summary : Computational methods impact all aspects of modern drug discovery and most notably these methods move rapidly from academic exercises to becoming drugs in clinical trials... This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of ...

Structure Based Drug Design

Structure Based Drug Design
  • Author : Pandi Veerapandian
  • Publisher : Routledge
  • Release Date : 2018-03-29
  • Total pages : 664
  • ISBN : 0128134283
GET BOOK

Summary : Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV ...

Structure based Design of Drugs and Other Bioactive Molecules

Structure based Design of Drugs and Other Bioactive Molecules
  • Author : Arun K. Ghosh,Sandra Gemma
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • Total pages : 474
  • ISBN : 0128134283
GET BOOK

Summary : Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary ...

Lead Generation Using a Privileged Structure based Approach

Lead Generation Using a Privileged Structure based Approach
  • Author : Sivakumar Annadurai
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 362
  • ISBN : 0128134283
GET BOOK

Summary : In drug discovery there are several approaches to lead generation and one traditional approach involves the synthesis and screening of a structurally diverse compound library against a number of biological targets to identify high affinity lead compounds. The use of a `privileged' structure-based compound library represents a viable approach that ...

Bioactive Peptides in Drug Discovery and Design

Bioactive Peptides in Drug Discovery and Design
  • Author : John Matsoukas,Thomas Mavromoustakos
  • Publisher : IOS Press
  • Release Date : 1999
  • Total pages : 300
  • ISBN : 0128134283
GET BOOK

Summary : As in previous editions, the focus in ESSENTIAL MATHEMATICS with APPLICATIONS remains on the Aufmann Interactive Method (AIM). Students are encouraged to be active participants in the classroom and in their own studies as they work through the How To examples and the paired Examples and You Try It problems. ...

Chemogenomics in Drug Discovery

Chemogenomics in Drug Discovery
  • Author : Hugo Kubinyi,Gerhard Müller
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • Total pages : 487
  • ISBN : 0128134283
GET BOOK

Summary : Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research ...

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
  • Author : Bimal K. Banik
  • Publisher : Advances in Green Chemistry
  • Release Date : 2020-04
  • Total pages : 610
  • ISBN : 0128134283
GET BOOK

Summary : Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. ...