Drug Discovery and Evaluation Methods in Clinical Pharmacology

Written By H.Gerhard Vogel
Drug Discovery and Evaluation  Methods in Clinical Pharmacology
  • Publsiher : Springer Science & Business Media
  • Release : 15 December 2010
  • ISBN : 3540898905
  • Pages : 564 pages
  • Rating : 5/5 from 1 reviews
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Read or download book entitled Drug Discovery and Evaluation Methods in Clinical Pharmacology written by H.Gerhard Vogel which was release on 15 December 2010, this book published by Springer Science & Business Media. Available in PDF, EPUB and Kindle Format. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Drug Discovery and Evaluation Methods in Clinical Pharmacology

Drug Discovery and Evaluation  Methods in Clinical Pharmacology
  • Author : H.Gerhard Vogel,Jochen Maas,Alexander Gebauer
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-15
  • Total pages : 564
  • ISBN : 3540898905
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Summary : Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these ...

Pharmacology in Drug Discovery and Development

Pharmacology in Drug Discovery and Development
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release Date : 2016-10-21
  • Total pages : 350
  • ISBN : 3540898905
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Summary : Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book ...

Molecular Pharmacology

Molecular Pharmacology
  • Author : John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam
  • Publisher : John Wiley & Sons
  • Release Date : 2012-11-30
  • Total pages : 424
  • ISBN : 3540898905
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Summary : This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of ...

Pharmacology for Chemists

Pharmacology for Chemists
  • Author : Raymond Hill,Terry Kenakin,Tom Blackburn
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-10-25
  • Total pages : 524
  • ISBN : 3540898905
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Summary : Assuming little previous knowledge of biology, this book aids graduate chemists to close the gap in their knowledge of pharmacology and make the link between medicinal chemistry and the way in which drugs act on the body. The availability of receptor structures has revolutionized drug discovery and development necessitating an ...

Drug Discovery and Evaluation Pharmacological Assays

Drug Discovery and Evaluation  Pharmacological Assays
  • Author : Franz J. Hock
  • Publisher : Springer
  • Release Date : 2015-11-14
  • Total pages : 2400
  • ISBN : 3540898905
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Summary : The 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining ...

Drug Discovery and Development Third Edition

Drug Discovery and Development  Third Edition
  • Author : James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
  • Publisher : CRC Press
  • Release Date : 2019-11-21
  • Total pages : 668
  • ISBN : 3540898905
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Summary : Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of ...

Drug Discovery and Development E Book

Drug Discovery and Development   E Book
  • Author : Raymond G Hill
  • Publisher : Elsevier Health Sciences
  • Release Date : 2012-07-20
  • Total pages : 368
  • ISBN : 3540898905
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Summary : The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from ...

Drug Discovery Development

Drug Discovery   Development
  • Author : Bhushan Patwardhan
  • Publisher : New India Publishing
  • Release Date : 2007
  • Total pages : 362
  • ISBN : 3540898905
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Summary : While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have ...

Quantitative Molecular Pharmacology and Informatics in Drug Discovery

Quantitative Molecular Pharmacology and Informatics in Drug Discovery
  • Author : Michael Lutz,Terry Kenakin
  • Publisher : John Wiley & Sons
  • Release Date : 2000-01-10
  • Total pages : 438
  • ISBN : 3540898905
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Summary : Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the ...

Drug Discovery and Development E Book

Drug Discovery and Development E Book
  • Author : Raymond G Hill,Duncan Richards
  • Publisher : Elsevier Health Sciences
  • Release Date : 2021-05-16
  • Total pages : 384
  • ISBN : 3540898905
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Summary : With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access. ...

Short Protocols in Pharmacology and Drug Discovery

Short Protocols in Pharmacology and Drug Discovery
  • Author : Salvatore J. Enna
  • Publisher : Current Protocols
  • Release Date : 2007-02-02
  • Total pages : 916
  • ISBN : 3540898905
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Summary : Short Protocols in Pharmacology and Drug Discovery provides condensed descriptions of more than 350 methods compiled from the successful title Current Protocols in Pharmacology. The book is specifically designed to provide quick access to step-by-step instructions for the essential methods used in every major area of pharmaceutical research, and especially stresses ...

A Pharmacology Primer

A Pharmacology Primer
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release Date : 2018-10-26
  • Total pages : 488
  • ISBN : 3540898905
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Summary : A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. ...

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery
  • Author : Alexander Hillisch,Rolf Hilgenfeld
  • Publisher : Birkhäuser
  • Release Date : 2012-11-28
  • Total pages : 292
  • ISBN : 3540898905
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Summary : Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach ...

Insights in Experimental Pharmacology and Drug Discovery 2021

Insights in Experimental Pharmacology and Drug Discovery  2021
  • Author : Salvatore Salomone,Andres Trostchansky
  • Publisher : Frontiers Media SA
  • Release Date : 2022-03-18
  • Total pages : 212
  • ISBN : 3540898905
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Summary : Download or read online Insights in Experimental Pharmacology and Drug Discovery 2021 written by Salvatore Salomone,Andres Trostchansky, published by Frontiers Media SA which was released on 2022-03-18. Get Insights in Experimental Pharmacology and Drug Discovery 2021 Books now! Available in PDF, ePub and Kindle....

Drug Discovery and Evaluation

Drug Discovery and Evaluation
  • Author : H. Gerhard Vogel,Jochen Maas,Franz Jakob Hock,Dieter Mayer
  • Publisher : Springer Science & Business Media
  • Release Date : 2006
  • Total pages : 889
  • ISBN : 3540898905
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Summary : This book is a landmark in the continuously changing world of drugs. It is essential reading for scientists and managers in the pharmaceutical industry who are involved in drug finding, drug development and decision making in the development process....