Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Written By Carlo Sala
Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
  • Publsiher : Academic Press
  • Release : 01 April 2016
  • ISBN : 9780128001097
  • Pages : 600 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability written by Carlo Sala which was release on 01 April 2016, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Autism Spectrum Disorders are lifelong neurodevelopmental disorders with early clinical presentation that affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite its high prevalence and insidious nature, there remains to be an extensive resource that provides information about the background and state of current research in the autism field. The first edition of Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. This volume discusses these neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. *Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities *Describes the genes implicated in ASDs and their function *Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies *Thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
  • Author : Carlo Sala,Chiara Verpelli
  • Publisher : Academic Press
  • Release Date : 2016-04-01
  • Total pages : 600
  • ISBN : 9780128001097
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Summary : Autism Spectrum Disorders are lifelong neurodevelopmental disorders with early clinical presentation that affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into ...

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
  • Author : Carlo Sala,Chiara Verpelli
  • Publisher : Academic Press
  • Release Date : 2016-04-30
  • Total pages : 394
  • ISBN : 9780128001097
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Summary : Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest ...

Shankopathies Shank Protein Deficiency Induced Synaptic Diseases

Shankopathies  Shank Protein Deficiency Induced Synaptic Diseases
  • Author : Elodie Ey,Thomas Bourgeron,Tobias Maria Boeckers,Eunjoon Kim,Kihoon Han
  • Publisher : Frontiers Media SA
  • Release Date : 2020-03-10
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : Download or read online Shankopathies Shank Protein Deficiency Induced Synaptic Diseases written by Elodie Ey,Thomas Bourgeron,Tobias Maria Boeckers,Eunjoon Kim,Kihoon Han, published by Frontiers Media SA which was released on 2020-03-10. Get Shankopathies Shank Protein Deficiency Induced Synaptic Diseases Books now! Available in PDF, ePub and ...

Neural and Synaptic Defects in Autism Spectrum Disorders

Neural and Synaptic Defects in Autism Spectrum Disorders
  • Author : Hansen Wang,Laurie C. Doering
  • Publisher : Frontiers Media SA
  • Release Date : 2015-07-07
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and ...

Autism Signaling Pathways

Autism Signaling Pathways
  • Author : Yu-Chih Lin,Yi-Ping Hsueh
  • Publisher : Frontiers Media SA
  • Release Date : 2021-11-23
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : Download or read online Autism Signaling Pathways written by Yu-Chih Lin,Yi-Ping Hsueh, published by Frontiers Media SA which was released on 2021-11-23. Get Autism Signaling Pathways Books now! Available in PDF, ePub and Kindle....

Autism

Autism
  • Author : Michael Fitzgerald,Jane Yip
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-04-12
  • Total pages : 344
  • ISBN : 9780128001097
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Summary : This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals ...

Autism Innovations and Future Directions in Psychological Research

Autism  Innovations and Future Directions in Psychological Research
  • Author : Emma Gowen,Christine M. Falter-Wagner,Laura Crane
  • Publisher : Frontiers Media SA
  • Release Date : 2022-02-14
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : Download or read online Autism Innovations and Future Directions in Psychological Research written by Emma Gowen,Christine M. Falter-Wagner,Laura Crane, published by Frontiers Media SA which was released on 2022-02-14. Get Autism Innovations and Future Directions in Psychological Research Books now! Available in PDF, ePub and Kindle....

Neuronal Stress Pathways Influence Synaptic Development and Nervous System Function in Drosophila Melanogaster

Neuronal Stress Pathways Influence Synaptic Development and Nervous System Function in Drosophila Melanogaster
  • Author : Alexandra Russo
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 122
  • ISBN : 9780128001097
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Summary : Synaptic development is a complex and highly orchestrated process in which the nervous system must build appropriately sized and sufficiently strong connections between neurons and their targets. Many neurodevelopmental disorders are caused by dysregulation of the mechanisms that promote the formation of normal synaptic connections. Here, I show that dysregulation ...

Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update Volume 2

Autism Spectrum Disorders  Developmental Trajectories  Neurobiological Basis  Treatment Update Volume 2
  • Author : Roberto Canitano,Yuri Bozzi,Dirk Dhossche
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-03
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : Download or read online Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update Volume 2 written by Roberto Canitano,Yuri Bozzi,Dirk Dhossche, published by Frontiers Media SA which was released on 2020-07-03. Get Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update Volume 2 Books now! Available in PDF, ePub ...

Autism Spectrum Disorders From Genotypes to Phenotypes

Autism Spectrum Disorders  From Genotypes to Phenotypes
  • Author : Valsamma Eapen,Andrew J. Whitehouse,Charles Claudianos,Rudi Crncec
  • Publisher : Frontiers Media SA
  • Release Date : 2015-12-10
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between ...

Translational Anatomy and Cell Biology of Autism Spectrum Disorder

Translational Anatomy and Cell Biology of Autism Spectrum Disorder
  • Author : Michael J. Schmeisser,Tobias M. Boeckers
  • Publisher : Springer
  • Release Date : 2017-05-25
  • Total pages : 211
  • ISBN : 9780128001097
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Summary : Autism spectrum disorder (ASD) affects approximately 1 % of the human population and is characterized by a core symptomatology including deficits in social interaction and repetitive patterns of behaviour plus various co-morbidities. Although a lot of progress has been made to uncover underlying causes and mechanisms throughout the last decade, we are ...

Homeostatic and Retrograde Signaling Mechanisms Modulating Presynaptic Function and Plasticity

Homeostatic and Retrograde Signaling Mechanisms Modulating Presynaptic Function and Plasticity
  • Author : Michael A. Sutton,Dion Dickman
  • Publisher : Frontiers Media SA
  • Release Date : 2016-01-06
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neuron, synapse, circuit, or entire network, and ...

The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders
  • Author : Joseph D. Buxbaum,Patrick R. Hof
  • Publisher : Academic Press
  • Release Date : 2012-12-31
  • Total pages : 496
  • ISBN : 9780128001097
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Summary : Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped ...

Biometals in Autism Spectrum Disorders

Biometals in Autism Spectrum Disorders
  • Author : Andreas Grabrucker
  • Publisher : Academic Press
  • Release Date : 2020-07-08
  • Total pages : 222
  • ISBN : 9780128001097
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Summary : Biometals in Autism Spectrum Disorders focuses on trace metals and autism. Compared to other references examining ASDs or metallomics, this book presents findings of abnormal metal homeostasis in ASD, providing an overview of current findings on trace metal biology, its role in ASD etiology, and how abnormal trace metal biology ...

Metabolic Disorders Associated with Autism Spectrum Disorders Approaches for Intervention

Metabolic Disorders Associated with Autism Spectrum Disorders  Approaches for Intervention
  • Author : Joana M. Gaspar,Humberto M. Carvalho,Alberto Camacho-Morales
  • Publisher : Frontiers Media SA
  • Release Date : 2022-01-20
  • Total pages : 212
  • ISBN : 9780128001097
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Summary : Download or read online Metabolic Disorders Associated with Autism Spectrum Disorders Approaches for Intervention written by Joana M. Gaspar,Humberto M. Carvalho,Alberto Camacho-Morales, published by Frontiers Media SA which was released on 2022-01-20. Get Metabolic Disorders Associated with Autism Spectrum Disorders Approaches for Intervention Books now! Available in ...