Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Written By Pierfausto Seneci
Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Publsiher : Academic Press
  • Release : 07 October 2014
  • ISBN : 0128004991
  • Pages : 314 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Molecular Targets in Protein Misfolding and Neurodegenerative Disease written by Pierfausto Seneci which was release on 07 October 2014, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2014-10-07
  • Total pages : 314
  • ISBN : 0128004991
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Summary : Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical ...

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-14
  • Total pages : 260
  • ISBN : 0128004991
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Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases
  • Author : Richard I. Morimoto,Yves Christen
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-13
  • Total pages : 136
  • ISBN : 0128004991
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Summary : The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of ...

Protein Misfolding in Neurodegenerative Diseases

Protein Misfolding in Neurodegenerative Diseases
  • Author : Robert D. E. Sewell
  • Publisher : CRC Press
  • Release Date : 2007-12-03
  • Total pages : 592
  • ISBN : 0128004991
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Summary : Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet ...

Protein Chaperones and Protection from Neurodegenerative Diseases

Protein Chaperones and Protection from Neurodegenerative Diseases
  • Author : Stephan N. Witt
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • Total pages : 444
  • ISBN : 0128004991
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Summary : How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different ...

Molecular Chaperones and Neurodegeneration

Molecular Chaperones and Neurodegeneration
  • Author : Cintia Roodveldt,Tiago F. Outeiro,Janice E. Braun
  • Publisher : Frontiers Media SA
  • Release Date : 2017-12-06
  • Total pages : 212
  • ISBN : 0128004991
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Summary : Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many ...

Molecular Chaperones and Protein Folding As Therapeutic Targets in Parkinson s Disease and Other Synucleinopathies

Molecular Chaperones and Protein Folding As Therapeutic Targets in Parkinson s Disease and Other Synucleinopathies
  • Author : Applied Research Applied Research Press
  • Publisher : CreateSpace
  • Release Date : 2015-08-09
  • Total pages : 44
  • ISBN : 0128004991
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Summary : Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson's disease, folding, post-translational modification and recycling of the synaptic protein alpha-synuclein are clearly altered, leading to a progressive accumulation of pathogenic protein species and the formation of intracellular inclusion ...

Protein and Peptide Folding Misfolding and Non Folding

Protein and Peptide Folding  Misfolding  and Non Folding
  • Author : Reinhard Schweitzer-Stenner
  • Publisher : John Wiley & Sons
  • Release Date : 2012-02-08
  • Total pages : 576
  • ISBN : 0128004991
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Summary : Sheds new light on intrinsically disordered proteins andpeptides, including their role in neurodegenerative diseases With the discovery of intrinsically disordered proteins andpeptides (IDPs), researchers realized that proteins do notnecessarily adopt a well defined secondary and tertiary structurein order to perform biological functions. In fact, IDPs playbiologically relevant roles, acting as ...

Genotype Proteotype Phenotype Relationships in Neurodegenerative Diseases

Genotype   Proteotype   Phenotype Relationships in Neurodegenerative Diseases
  • Author : J. Cummings,J. Hardy,M. Poncet
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-03-30
  • Total pages : 166
  • ISBN : 0128004991
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Summary : Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships. Experts from international laboratories contributed to the current volume to produce a comprehensive overview of the role of protein misfolding in neurodegeneration. Links between genotype and protein characteristics ...

Protein Folding Disorders Of The Central Nervous System

Protein Folding Disorders Of The Central Nervous System
  • Author : Ghiso Jorge A,Rostagno Agueda A
  • Publisher : World Scientific
  • Release Date : 2017-09-15
  • Total pages : 336
  • ISBN : 0128004991
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Summary : This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." ...

Metal Based Neurodegeneration

Metal Based Neurodegeneration
  • Author : Robert Crichton,Roberta Ward
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-04
  • Total pages : 440
  • ISBN : 0128004991
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Summary : Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a ...

Neurodegenerative Diseases

Neurodegenerative Diseases
  • Author : Jagan A Pillai PhD
  • Publisher : Oxford University Press
  • Release Date : 2016-10-17
  • Total pages : 304
  • ISBN : 0128004991
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Summary : As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research. Neurodegenerative Diseases: ...

Neurodegeneration

Neurodegeneration
  • Author : Danilo Milardi,Enrico Rizzarelli
  • Publisher : Royal Society of Chemistry
  • Release Date : 2011-06-24
  • Total pages : 284
  • ISBN : 0128004991
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Summary : Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed "amyloid") in the brain. ...

Protein Misfolding Disorders

Protein Misfolding Disorders
  • Author : Claudio Hetz
  • Publisher : Bentham Science Publishers
  • Release Date : 2009
  • Total pages : 147
  • ISBN : 0128004991
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Summary : Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding ...

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
  • Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-08-06
  • Total pages : 490
  • ISBN : 0128004991
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Summary : The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the ...