Molecular Mechanisms of Dementia

Written By Wilma Wasco
Molecular Mechanisms of Dementia
  • Publsiher : Springer Science & Business Media
  • Release : 01 November 1996
  • ISBN : 1592594719
  • Pages : 312 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Molecular Mechanisms of Dementia written by Wilma Wasco which was release on 01 November 1996, this book published by Springer Science & Business Media. Available in PDF, EPUB and Kindle Format. Book excerpt: The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia
  • Author : Wilma Wasco,Rudolph Tanzi
  • Publisher : Springer Science & Business Media
  • Release Date : 1996-11-01
  • Total pages : 312
  • ISBN : 1592594719
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Summary : The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment ...

Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia
  • Author : Akhlaq A. Farooqui
  • Publisher : Academic Press
  • Release Date : 2019-04-15
  • Total pages : 386
  • ISBN : 1592594719
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Summary : Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of ...

Molecular Mechanisms of Aging

Molecular Mechanisms of Aging
  • Author : Konrad Beyreuther,Gotthard Schettler
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 206
  • ISBN : 1592594719
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Summary : Download or read online Molecular Mechanisms of Aging written by Konrad Beyreuther,Gotthard Schettler, published by Springer Science & Business Media which was released on 2012-12-06. Get Molecular Mechanisms of Aging Books now! Available in PDF, ePub and Kindle....

Neurodegeneration

Neurodegeneration
  • Author : Dennis Dickson,Roy O. Weller
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-09
  • Total pages : 432
  • ISBN : 1592594719
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Summary : Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the ...

Molecular Mechanisms of Extracellular and Intracellular Proteinopathy in Alzheimer s Disease and Frontotemporal Dementia

Molecular Mechanisms of Extracellular and Intracellular Proteinopathy in Alzheimer s Disease and Frontotemporal Dementia
  • Author : Nicolae-Daniel Pirici
  • Publisher : Unknown
  • Release Date : 2009
  • Total pages : 209
  • ISBN : 1592594719
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Summary : Download or read online Molecular Mechanisms of Extracellular and Intracellular Proteinopathy in Alzheimer s Disease and Frontotemporal Dementia written by Nicolae-Daniel Pirici, published by which was released on 2009. Get Molecular Mechanisms of Extracellular and Intracellular Proteinopathy in Alzheimer s Disease and Frontotemporal Dementia Books now! Available in PDF, ePub and ...

Autophagy

Autophagy
  • Author : S. Tariq Ahmad,Jin-A. Lee
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 360
  • ISBN : 1592594719
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Summary : Autophagy is a highly regulated process that promotes vital cellular homeostasis by allowing bulk non-specific degradation of the cytoplasmic contents, mainly damaged and/or surplus organelles and proteins. Autophagy is ubiquitous in eukaryotes, highly conserved from yeast to mammals, and occurs in all mammalian tissues. Historically, autophagy was characterized as ...

The Involvement of Molecular Mechanisms in the Pathogenesis of AIDS Dementia Complex

The Involvement of Molecular Mechanisms in the Pathogenesis of AIDS Dementia Complex
  • Author : Louise Ann Pemberton
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 300
  • ISBN : 1592594719
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Summary : Download or read online The Involvement of Molecular Mechanisms in the Pathogenesis of AIDS Dementia Complex written by Louise Ann Pemberton, published by which was released on 2006. Get The Involvement of Molecular Mechanisms in the Pathogenesis of AIDS Dementia Complex Books now! Available in PDF, ePub and Kindle....

Metal Based Neurodegeneration

Metal Based Neurodegeneration
  • Author : Robert Crichton,Roberta Ward
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-04
  • Total pages : 440
  • ISBN : 1592594719
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Summary : Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a ...

Protein Misfolding Aggregation and Conformational Diseases

Protein Misfolding  Aggregation and Conformational Diseases
  • Author : Vladimir N. Uversky,Anthony Fink
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-26
  • Total pages : 538
  • ISBN : 1592594719
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Summary : The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders....

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases
  • Author : Marie-Francoise Chesselet
  • Publisher : Springer Science & Business Media
  • Release Date : 2000-10-19
  • Total pages : 410
  • ISBN : 1592594719
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Summary : With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to ...

Neurodegenerative Diseases

Neurodegenerative Diseases
  • Author : Nagehan Ersoy Tunalı
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-01-20
  • Total pages : 178
  • ISBN : 1592594719
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Summary : Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The ...

Alzheimer s Disease

Alzheimer s Disease
  • Author : Sangram S. Sisodia,Rudolph E. Tanzi
  • Publisher : Springer
  • Release Date : 2006-12-28
  • Total pages : 286
  • ISBN : 1592594719
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Summary : This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, ...

Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer s Disease and Frontotemporal Dementia

Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer s Disease and Frontotemporal Dementia
  • Author : Nicolae-Daniel Pirici
  • Publisher : Unknown
  • Release Date : 2012
  • Total pages : 215
  • ISBN : 1592594719
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Summary : Download or read online Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer s Disease and Frontotemporal Dementia written by Nicolae-Daniel Pirici, published by which was released on 2012. Get Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer s Disease and Frontotemporal Dementia Books now! Available in PDF, ePub and ...

Molecular Mechanisms of the Aging Process and Rejuvenation

Molecular Mechanisms of the Aging Process and Rejuvenation
  • Author : Naofumi Shiomi
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-08-31
  • Total pages : 126
  • ISBN : 1592594719
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Summary : Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging ...

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2018-03-29
  • Total pages : 560
  • ISBN : 1592594719
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Summary : The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters ...