Intrinsically Disordered Proteins

Written By Vladimir N. Uversky
Intrinsically Disordered Proteins
  • Publsiher : Springer
  • Release : 05 August 2014
  • ISBN : 3319089218
  • Pages : 61 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Intrinsically Disordered Proteins written by Vladimir N. Uversky which was release on 05 August 2014, this book published by Springer. Available in PDF, EPUB and Kindle Format. Book excerpt: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Vladimir N. Uversky
  • Publisher : Springer
  • Release Date : 2014-08-05
  • Total pages : 61
  • ISBN : 3319089218
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Summary : In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their ...

Structure and Function of Intrinsically Disordered Proteins

Structure and Function of Intrinsically Disordered Proteins
  • Author : Peter Tompa,Alan Fersht
  • Publisher : CRC Press
  • Release Date : 2009-11-18
  • Total pages : 359
  • ISBN : 3319089218
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Summary : The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-11-21
  • Total pages : 754
  • ISBN : 3319089218
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Summary : Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Nicola Salvi
  • Publisher : Academic Press
  • Release Date : 2019-06-14
  • Total pages : 355
  • ISBN : 3319089218
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Summary : Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new ...

Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology

Dancing Protein Clouds  Intrinsically Disordered Proteins in the Norm and Pathology
  • Author : Vladimir Uversky
  • Publisher : Academic Press
  • Release Date : 2019-09-15
  • Total pages : 424
  • ISBN : 3319089218
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Summary : "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their ...

Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C

Dancing Protein Clouds  Intrinsically Disordered Proteins in the Norm and Pathology  Part C
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-10-14
  • Total pages : 434
  • ISBN : 3319089218
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Summary : Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of ...

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Intrinsically Disordered Proteins Studied by NMR Spectroscopy
  • Author : Isabella C. Felli,Roberta Pierattelli
  • Publisher : Springer
  • Release Date : 2015-09-19
  • Total pages : 421
  • ISBN : 3319089218
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Summary : This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in ...

Dancing Protein Clouds Intrinsically Disordered Proteins in Health and Disease Part B

Dancing Protein Clouds  Intrinsically Disordered Proteins in Health and Disease  Part B
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-08-19
  • Total pages : 402
  • ISBN : 3319089218
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Summary : Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and ...

Instrumental Analysis of Intrinsically Disordered Proteins

Instrumental Analysis of Intrinsically Disordered Proteins
  • Author : Vladimir Uversky,Sonia Longhi
  • Publisher : John Wiley & Sons
  • Release Date : 2011-01-31
  • Total pages : 600
  • ISBN : 3319089218
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Summary : Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Nicola Salvi
  • Publisher : Academic Press
  • Release Date : 2019-09-15
  • Total pages : 328
  • ISBN : 3319089218
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Summary : A growing body of evidence highlights the importance of intrinsically disordered proteins (IDPs) and regions (IDRs) in fundamental cellular functions and biochemical processes. Increasing evidence associates alterations in the expression levels or activity of IDPs with human pathologies; and, in recent years, researchers have placed stronger emphasis on developing computational ...

Protein Misfolding Aggregation and Conformational Diseases

Protein Misfolding  Aggregation and Conformational Diseases
  • Author : Vladimir N. Uversky,Anthony Fink
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-26
  • Total pages : 538
  • ISBN : 3319089218
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Summary : The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders....

Functionally Relevant Macromolecular Interactions of Disordered Proteins

Functionally Relevant Macromolecular Interactions of Disordered Proteins
  • Author : Istvan Simon
  • Publisher : MDPI
  • Release Date : 2021-01-20
  • Total pages : 520
  • ISBN : 3319089218
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Summary : Disordered proteins are relatively recent newcomers in protein science. They were first described in detail by Wright and Dyson, in their J. Mol. Biol. paper in 1999. First, it was generally thought for more than a decade that disordered proteins or disordered parts of proteins have different amino acid compositions than ...

Intrinsically Disordered Protein Analysis

Intrinsically Disordered Protein Analysis
  • Author : Vladimir N. Uversky,A. Keith Dunker
  • Publisher : Springer
  • Release Date : 2012-07-21
  • Total pages : 454
  • ISBN : 3319089218
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Summary : Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis: Methods ...

Intrinsically Disordered Proteins in Molecular Recognition and Structural Proteomics

Intrinsically Disordered Proteins in Molecular Recognition and Structural Proteomics
  • Author : Christopher John Oldfield
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 264
  • ISBN : 3319089218
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Summary : Intrinsically disordered proteins (IDPs) are abundant in nature, being more prevalent in the proteomes of eukaryotes than those of bacteria or archaea. As introduced in Chapter I, these proteins, or portions of these proteins, lack stable equilibrium structures and instead have dynamic conformations that vary over time and population. Despite ...

Interfaces of Intrinsically Disordered Proteins

Interfaces of Intrinsically Disordered Proteins
  • Author : Büşra Topal
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 84
  • ISBN : 3319089218
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Summary : Download or read online Interfaces of Intrinsically Disordered Proteins written by Büşra Topal, published by which was released on 2013. Get Interfaces of Intrinsically Disordered Proteins Books now! Available in PDF, ePub and Kindle....