Genetics of Bone Biology and Skeletal Disease

Written By Rajesh V. Thakker
Genetics of Bone Biology and Skeletal Disease
  • Publsiher : Academic Press
  • Release : 31 October 2017
  • ISBN : 0128041986
  • Pages : 878 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker which was release on 31 October 2017, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease
  • Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
  • Publisher : Academic Press
  • Release Date : 2017-10-31
  • Total pages : 878
  • ISBN : 0128041986
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Summary : Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each ...

The Genetics of Osteoporosis and Metabolic Bone Disease

The Genetics of Osteoporosis and Metabolic Bone Disease
  • Author : Michael J. Econs
  • Publisher : Springer Science & Business Media
  • Release Date : 2000-05-12
  • Total pages : 462
  • ISBN : 0128041986
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Summary : The explosive growth in the field of molecular biology over the last two decades has started to make a great impact on clinical medicine. Genes have been cloned for diseases that were poorly understood only a decade ago. Additionally, investigators are increasingly aware that there are strong genetic components to ...

Principles of Bone Biology

Principles of Bone Biology
  • Author : John P. Bilezikian,T. John Martin,Thomas L. Clemens,Clifford Rosen
  • Publisher : Academic Press
  • Release Date : 2019-08-22
  • Total pages : 2024
  • ISBN : 0128041986
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Summary : Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone ...

Current Topics in Bone Biology

Current Topics in Bone Biology
  • Author : Hong-wen Deng,Yao-zhong Liu,Chun-Yuan Guo
  • Publisher : World Scientific
  • Release Date : 2005
  • Total pages : 528
  • ISBN : 0128041986
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Summary : This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic ...

Skeletal Biology and Medicine II

Skeletal Biology and Medicine II
  • Author : Mone Zaidi
  • Publisher : Wiley-Blackwell
  • Release Date : 2012-01-24
  • Total pages : 88
  • ISBN : 0128041986
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Summary : The volume features current basic, clinical, and translational research on aspects of skeletal morphogenesis and remodeling in health and disease. Papers survey vital new insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. Also covered are the effects of other physiological ...

Skeletal Biology and Medicine

Skeletal Biology and Medicine
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 87
  • ISBN : 0128041986
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Summary : "This second of two volumes from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27-30, 2011, features papers focussed on bone and cartilage homeostasis and bone disease. The two volumes in this series, 1240 and 1237, present current basic, ...

The Skeletal System

The Skeletal System
  • Author : Olivier Pourquié
  • Publisher : Unknown
  • Release Date : 2009
  • Total pages : 365
  • ISBN : 0128041986
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Summary : Geared toward scientists and clinicians, this book summarizes the current understanding of the development, biology, and evolution of the vertebrate skeleton. It covers such topics as the differentiation of chondrocytes, the origins and evolution of bone, and the genetics of human skeletal disease....

The Genetics of the Skeleton

The Genetics of the Skeleton
  • Author : David Roderick Johnson
  • Publisher : Oxford University Press, USA
  • Release Date : 1986
  • Total pages : 407
  • ISBN : 0128041986
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Summary : The effects of genetic mutations on the mammalian skeleton are a useful aid in understanding how the skeleton develops. This book describes these effects, using the mouse as a primary source for considering the precartilaginous, cartilaginous, and bony skeletons, regional anatomy, and the interactions between genes and teratogens. The author ...

Skeletal Biology and Medicine II

Skeletal Biology and Medicine II
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 87
  • ISBN : 0128041986
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Summary : "This second of two volumes from the 4th New York Skeletal Biology and Medicine Conference, held at Mount Sinai School of Medicine in New York City on April 27-30, 2011, features papers focussed on bone and cartilage homeostasis and bone disease. The two volumes in this series, 1240 and 1237, present current basic, ...

Advances in Pathobiology and Management of Paget s Disease of Bone

Advances in Pathobiology and Management of Paget   s Disease of Bone
  • Author : Sakamuri V. Reddy
  • Publisher : Academic Press
  • Release Date : 2016-04-28
  • Total pages : 158
  • ISBN : 0128041986
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Summary : Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as ...

Osteoimmunology

Osteoimmunology
  • Author : Joseph Lorenzo,Mark Horowitz,Yongwon Choi,Hiroshi Takayanagi,Georg Schett
  • Publisher : Academic Press
  • Release Date : 2015-09-23
  • Total pages : 376
  • ISBN : 0128041986
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Summary : Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers ...

Studies in Stomatology and Craniofacial Biology

Studies in Stomatology and Craniofacial Biology
  • Author : Meyer Michael Cohen,Bruce J. Baum
  • Publisher : IOS Press
  • Release Date : 1997
  • Total pages : 658
  • ISBN : 0128041986
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Summary : Studies in Stomatology and Craniofacial Biology contains 33 papers under the general headings of developmental biology, developmental pathology, acquired pathology, and gene therapy. The book covers the basic science of stomatology (diseases of the mouth) and craniofacial biology in general. The subject matter is wide in scope and utilizes a variety ...

The Aging Skeleton

The Aging Skeleton
  • Author : Clifford J. Rosen,Julie Glowacki,John P. Bilezikian
  • Publisher : Elsevier
  • Release Date : 1999-08-19
  • Total pages : 642
  • ISBN : 0128041986
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Summary : The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of ...

Vertebrate Skeletal Development

Vertebrate Skeletal Development
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-03-20
  • Total pages : 409
  • ISBN : 0128041986
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Summary : Vertebrate Skeletal Development, Volume 133, the latest release in the Current Topics in Developmental Biology series, presents interesting chapters on a variety of topics, with this edition focusing on Craniofacial skeletal development, Regulatory mechanism of jawbone and tooth development, Development of the axial skeleton and intervertebral discs, Stem and progenitor cells ...

Translational Endocrinology of Bone

Translational Endocrinology of Bone
  • Author : Gerard Karsenty
  • Publisher : Academic Press
  • Release Date : 2013
  • Total pages : 226
  • ISBN : 0128041986
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Summary : The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. First, the use of mouse genetics, guided by clinical observations has revealed, besides the classical regulation by the parathyroid hormone ...