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Read or download book entitled Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy written by Anonim which was release on 07 November 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner Describes the involvement of efflux pumps in cancer resistance in different cancer types Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance
- Author : Anonim
- Publisher : Academic Press
- Release Date : 2019-11-07
- Total pages : 394
- ISBN : 0128141417
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Summary : Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette ...
- Author : Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
- Publisher : Springer
- Release Date : 2017-03-21
- Total pages : 630
- ISBN : 0128141417
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Summary : This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research ...
- Author : Kara Michelle Pearson
- Publisher : Unknown
- Release Date : 2000
- Total pages : 132
- ISBN : 0128141417
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Summary : Download or read online Using Natural Products to Elucidate a Multidrug Resistance Pathway written by Kara Michelle Pearson, published by which was released on 2000. Get Using Natural Products to Elucidate a Multidrug Resistance Pathway Books now! Available in PDF, ePub and Kindle....
- Author : Martin Clynes
- Publisher : Springer Science & Business Media
- Release Date : 2013-04-17
- Total pages : 344
- ISBN : 0128141417
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Summary : Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently ...
- Author : Anonim
- Publisher : Academic Press
- Release Date : 2021-08-11
- Total pages : 388
- ISBN : 0128141417
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Summary : Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory ...
- Author : Chi Hin Cho,Tao Hu
- Publisher : Academic Press
- Release Date : 2020-05-24
- Total pages : 240
- ISBN : 0128141417
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Summary : Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug ...
- Author : Andrew Freywald,Franco Vizeacoumar
- Publisher : Academic Press
- Release Date : 2020-12-04
- Total pages : 308
- ISBN : 0128141417
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Summary : Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This ...
- Author : Stefania Nobili,Enrico Mini,Chiara Riganti
- Publisher : Unknown
- Release Date : 2015-07-06
- Total pages : 212
- ISBN : 0128141417
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Summary : More than 40 years ago, the observation that doxorubicin-resistant tumor cells were cross-resistant to several structurally different anticancer agents was the first step in the discovery of P-glycoprotein (P-gp). P-gp belongs to the superfamily of ATP-binding cassette (ABC) transporters;its overexpression has become a therapeutic target for overcoming multidrug resistance in ...
- Author : Anonim
- Publisher : Academic Press
- Release Date : 2022-01-14
- Total pages : 294
- ISBN : 0128141417
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Summary : Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book ...
- Author : Luc Friboulet
- Publisher : Academic Press
- Release Date : 2021-01-18
- Total pages : 216
- ISBN : 0128141417
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Summary : Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ...
- Author : Ripudaman Singh
- Publisher : Unknown
- Release Date : 2012
- Total pages : 220
- ISBN : 0128141417
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Summary : The PI3kinase pathway and ABC transporters play a crucial role in normal growth, survival and death of a cell. However in cancer cells, disturbances in these pathways lead to uncontrolled growth even under treatment of various anticancer drugs. Two major efflux pumps i.e. p-glycoprotein (Pgp) and multidrug resistance ...
- Author : Goli Samimi,Christina Annunziata
- Publisher : Academic Press
- Release Date : 2020-11-06
- Total pages : 188
- ISBN : 0128141417
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Summary : Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, ...
- Author : Loutfy H. Madkour
- Publisher : CRC Press
- Release Date : 2022-03-03
- Total pages : 558
- ISBN : 0128141417
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Summary : The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book ...
- Author : Ramasamy Paulmurugan,Tarik F. Massoud
- Publisher : Academic Press
- Release Date : 2021-06-25
- Total pages : 828
- ISBN : 0128141417
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Summary : Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and ...
- Author : Ali Syed Arbab
- Publisher : Academic Press
- Release Date : 2021-03-05
- Total pages : 202
- ISBN : 0128141417
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Summary : New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect ...
