Alzheimer s Disease Drug Development

Written By Jeffrey Cummings
Alzheimer s Disease Drug Development
  • Publsiher : Cambridge University Press
  • Release : 31 March 2022
  • ISBN : 1108985157
  • Pages : 212 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Alzheimer s Disease Drug Development written by Jeffrey Cummings which was release on 31 March 2022, this book published by Cambridge University Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Alzheimer's Disease (AD) is a growing global public health challenge. The development of new therapies is urgently needed, and a complex ecosystem of organizations has grown to facilitate AD drug discovery and development. Masterfully collating information on the drug development ecosystem, this book emphasizes the contributions of each aspect in the pipeline with a uniform approach to chapters, enabling readers to access relevant information quickly. Topics covered include the use of non-clinical laboratory studies, biomarker development, artificial intelligence, design and management of clinical trials, and funding and financing models. Also discussed is the critical role of advocacy fundraising for drug development. With the approval of aducanumab, the function of the ecosystem has become apparent. This is a definitive overview of how the ecosystem works in transferring an AD drug from its discovery in the laboratory through clinical trial testing to regulatory review and eventual marketing.

Alzheimer s Disease Drug Development

Alzheimer s Disease Drug Development
  • Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
  • Publisher : Cambridge University Press
  • Release Date : 2022-03-31
  • Total pages : 212
  • ISBN : 1108985157
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Summary : Alzheimer's Disease (AD) is a growing global public health challenge. The development of new therapies is urgently needed, and a complex ecosystem of organizations has grown to facilitate AD drug discovery and development. Masterfully collating information on the drug development ecosystem, this book emphasizes the contributions of each aspect in ...

Developing Therapeutics for Alzheimer s Disease

Developing Therapeutics for Alzheimer s Disease
  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2016-05-27
  • Total pages : 676
  • ISBN : 1108985157
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Summary : Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that ...

Alzheimer s Disease Modernizing Concept Biological Diagnosis and Therapy

Alzheimer s Disease   Modernizing Concept  Biological Diagnosis and Therapy
  • Author : M.C. Carrillo,H. Hampel
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2012-04-23
  • Total pages : 200
  • ISBN : 1108985157
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Summary : Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers ...

Prevent Of Alzheimers Disease

Prevent Of Alzheimers Disease
  • Author : Michael Grundman
  • Publisher : CRC Press
  • Release Date : 2004-11-11
  • Total pages : 350
  • ISBN : 1108985157
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Summary : Between 1974 and 1999 Alzheimer's disease has been the focus of research interest especially with the development of new therapeutic agents for the symptomatic agents treatment of the disease. The primary focus of this book is disease modification. The authors examine the underlying in the pathogenesis of Alzheimer's disease and data derived ...

Global Clinical Trials for Alzheimer s Disease

Global Clinical Trials for Alzheimer s Disease
  • Author : Menghis Bairu,Michael Weiner
  • Publisher : Academic Press
  • Release Date : 2013-08-28
  • Total pages : 432
  • ISBN : 1108985157
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Summary : Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical ...

Alzheimer s Disease Drug Development

Alzheimer s Disease Drug Development
  • Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
  • Publisher : Cambridge University Press
  • Release Date : 2022-03-31
  • Total pages : 387
  • ISBN : 1108985157
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Summary : Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models....

Thinking about Cognition

Thinking about Cognition
  • Author : Chris G. Kruse
  • Publisher : IOS Press
  • Release Date : 2006
  • Total pages : 133
  • ISBN : 1108985157
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Summary : "100 Years after the discovery of Alzheimers disease, neurological diseases and psychiatric disorders represent the largest and fastest growing unmet medical market with 2 billion affected people worldwide. Life expectancy of humans continues to increase, and the world population is aging. Advanced age may lead to deterioration of cognitive functions of the ...

Preclinical and clinical issues in Alzheimer s disease drug research and development

Preclinical and clinical issues in Alzheimer   s disease drug research and development
  • Author : Cesare Mancuso,Silvana Gaetani
  • Publisher : Frontiers Media SA
  • Release Date : 2015-03-03
  • Total pages : 212
  • ISBN : 1108985157
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Summary : Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor ...

Amazing Activities for Low Function Abilities and Caregiver Guide

Amazing Activities for Low Function Abilities and Caregiver Guide
  • Author : Amira Choukair Tame
  • Publisher : Trafford Publishing
  • Release Date : 2014-02-19
  • Total pages : 258
  • ISBN : 1108985157
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Summary : Hopefully, this book provides you with a systematic approach to reduce the emotional, functional and environmental effects of Alzheimers disease through the use of these therapeutic activities and creative techniques. The strongest emotional healers of wounds created by Alzheimers disease are love, care and respect. Alzheimers was not brought on ...

Autism Spectrum Disorder and Alzheimer s Disease

Autism Spectrum Disorder and Alzheimer s Disease
  • Author : Ghulam Md Ashraf
  • Publisher : Springer Nature
  • Release Date : 2021
  • Total pages : 315
  • ISBN : 1108985157
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Summary : This book talks about the multidimensional biological etiology of Alzheimers disease and autism spectrum disorder which leads to distinctive ways of perception, thinking and learning in affected individuals. It provides a deeper emphasis on the need for early diagnosis, continuous assessment of patients and the proper educational methods and environment ...

Contemporary Accounts in Drug Discovery and Development

Contemporary Accounts in Drug Discovery and Development
  • Author : Xianhai Huang,Robert G. Aslanian,Wayne H. Tang
  • Publisher : John Wiley & Sons
  • Release Date : 2022-03-29
  • Total pages : 480
  • ISBN : 1108985157
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Summary : CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. ...

Amyloid beta clearance in Alzheimer s disease

Amyloid beta clearance in Alzheimer   s disease
  • Author : Robert Marr,Eliezer Masliah
  • Publisher : Frontiers Media SA
  • Release Date : 2015-03-24
  • Total pages : 212
  • ISBN : 1108985157
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Summary : Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. ...

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release Date : 2019-11-23
  • Total pages : 356
  • ISBN : 1108985157
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Summary : Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second ...

Alzheimer s Disease

Alzheimer s Disease
  • Author : Adela Soliz
  • Publisher : Greenhaven Press, Incorporated
  • Release Date : 2006
  • Total pages : 170
  • ISBN : 1108985157
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Summary : Presents essays discussing Alzheimer's disease, including possible causes, research being done to find preventions or cures, and best ways to care for those with the disease....

Biological Diagnostic and Therapeutic Advances in Alzheimer s Disease

Biological  Diagnostic and Therapeutic Advances in Alzheimer s Disease
  • Author : Ghulam Md Ashraf,Athanasios Alexiou
  • Publisher : Springer Nature
  • Release Date : 2019-10-11
  • Total pages : 293
  • ISBN : 1108985157
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Summary : This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. ...