Design of Hybrid Molecules for Drug Development

Written By Michael Decker
Design of Hybrid Molecules for Drug Development
  • Publsiher : Elsevier
  • Release : 05 April 2017
  • ISBN : 0081011180
  • Pages : 352 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Design of Hybrid Molecules for Drug Development written by Michael Decker which was release on 05 April 2017, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development
  • Author : Michael Decker
  • Publisher : Elsevier
  • Release Date : 2017-04-05
  • Total pages : 352
  • ISBN : 0081011180
GET BOOK

Summary : Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules ...

Advanced Concepts and Applications

Advanced Concepts and Applications
  • Author : Fidele Ntie-Kang
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2021-11-22
  • Total pages : 343
  • ISBN : 0081011180
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Summary : Vol. 2 of Chemoinformatics of Natural Products introduces the reader to the currently available tools for toxicity prediction, drug property prediction, an enumeration of compounds, scaffolds and functional groups in nature, computational methods for lead identification, metabolite biosynthesis, etc. Selected case studies and hands-on tutorial exercises have been included....

Polypharmacology

Polypharmacology
  • Author : Zhiguo Wang,Baofeng Yang
  • Publisher : Springer Nature
  • Release Date : 2022-08-01
  • Total pages : 870
  • ISBN : 0081011180
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Summary : There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the ...

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
  • Author : Jens-Uwe Peters
  • Publisher : John Wiley & Sons
  • Release Date : 2012-01-20
  • Total pages : 536
  • ISBN : 0081011180
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Summary : An essential outline of the main facets of polypharmacology indrug discovery research Extending drug discovery opportunities beyond the "one drug, onetarget" philosophy, a polypharmacological approach to the treatmentof complex diseases is emerging as a hot topic in both industry andacademic research. Polypharmacology in Drug Discovery presents anoverview of the various ...

Chemical Drug Design

Chemical Drug Design
  • Author : Girish Kumar Gupta,Vinod Kumar
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2016-10-10
  • Total pages : 297
  • ISBN : 0081011180
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Summary : Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs....

Computational Medicinal Chemistry for Drug Discovery

Computational Medicinal Chemistry for Drug Discovery
  • Author : Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare
  • Publisher : CRC Press
  • Release Date : 2003-12-17
  • Total pages : 1169
  • ISBN : 0081011180
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Summary : Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computation, intermolecular behavior, ligand-receptor interaction, and modeling ...

Microbial Biotechnology

Microbial Biotechnology
  • Author : Bhima Bhukya,Anjana Devi Tangutur
  • Publisher : CRC Press
  • Release Date : 2017-03-16
  • Total pages : 448
  • ISBN : 0081011180
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Summary : The new volume takes an interdisciplinary look at current technical challenges and recent developmental trends in microbial biotechnology. It covers an avalanche of new information available through research by focusing on a broad spectrum of issues on different microorganisms and their recent applications and implications in agriculture, soil science and ...

Issues in Medical Chemistry 2012 Edition

Issues in Medical Chemistry  2012 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-01-10
  • Total pages : 245
  • ISBN : 0081011180
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Summary : Issues in Medical Chemistry / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Medicinal Chemistry. The editors have built Issues in Medical Chemistry: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Medicinal Chemistry in this eBook to be deeper than ...

Vicinal Diaryl Substituted Heterocycles

Vicinal Diaryl Substituted Heterocycles
  • Author : M. R. Yadav,P. R. Murumkar,R. B. Ghuge
  • Publisher : Elsevier
  • Release Date : 2018-03-14
  • Total pages : 430
  • ISBN : 0081011180
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Summary : Vicinal Diaryl-Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential therapeutic agents, the text goes ...

Drug Selectivity

Drug Selectivity
  • Author : Norbert Handler,Helmut Buschmann,Raimund Mannhold,Jörg Holenz
  • Publisher : John Wiley & Sons
  • Release Date : 2018-02-05
  • Total pages : 536
  • ISBN : 0081011180
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Summary : The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. ...

Antibiotic Materials in Healthcare

Antibiotic Materials in Healthcare
  • Author : Kokkarachedu Varaprasad,Vimala Kanikireddy,Rotimi Sadiku
  • Publisher : Academic Press
  • Release Date : 2020-05-22
  • Total pages : 346
  • ISBN : 0081011180
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Summary : Antibiotic Materials in Healthcare provides significant information on antibiotic related issues, accurate solutions, and recent investigative information for health-related applications. In addition, the book addresses the design and development of antibiotics with advanced (physical, chemical and biological) properties, an analysis of materials, in vivo and in vitro applications, and their ...

Imidazole Based Drug Discovery

Imidazole Based Drug Discovery
  • Author : Shikha Agarwal
  • Publisher : Elsevier
  • Release Date : 2021-12-10
  • Total pages : 372
  • ISBN : 0081011180
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Summary : Imidazole-Based Drug Discovery covers all categories of imidazole and its derivatives, synthesis, pharmacological applications and drug-based studies. Imidazole scaffolds act as a channel between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. This book provides detailed coverage of several greener synthetic protocols and pharmacological applications ...

Structure Based Drug Design for Diagnosis and Treatment of Neurological Diseases

Structure Based Drug Design for Diagnosis and Treatment of Neurological Diseases
  • Author : Rona R. Ramsay,Giuseppe Di Giovanni
  • Publisher : Frontiers Media SA
  • Release Date : 2017-03-24
  • Total pages : 212
  • ISBN : 0081011180
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Summary : European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: ...

Antimicrobial Drug Discovery

Antimicrobial Drug Discovery
  • Author : George Tegos,Eleftherios Mylonakis
  • Publisher : CABI
  • Release Date : 2012
  • Total pages : 357
  • ISBN : 0081011180
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Summary : Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the ...

Development of Hybrid Drugs for Cancer Treatment and Studies in Asymmetric Organocatalysis

Development of Hybrid Drugs for Cancer Treatment and Studies in Asymmetric Organocatalysis
  • Author : Dainis Kaldre
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 212
  • ISBN : 0081011180
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Summary : "This thesis is separated into two parts. In the first part design, synthesis and structure-activity relationships of the novel Vitamin D receptor (VDR) agonists and histone deacetylase (HDAC) inhibitors are presented. In the second part, the development of a new methodology to accelerate [3,3] sigmatropic rearrangements is presented.A promising approach ...