Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Written By Pierfausto Seneci
Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Publsiher : Academic Press
  • Release : 12 January 2015
  • ISBN : 9780128019443
  • Pages : 260 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKChemical Modulators of Protein Misfolding and Neurodegenerative Disease


Read or download book entitled Chemical Modulators of Protein Misfolding and Neurodegenerative Disease written by Pierfausto Seneci which was release on 12 January 2015, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. • Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds; • Provides discipline-specific chapters that cover medicinal chemistry and clinical applications; • Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder; • Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-12
  • Total pages : 260
  • ISBN : 9780128019443
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Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2015-01-14
  • Total pages : 260
  • ISBN : 9780128019443
GET BOOK

Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Author : Pierfausto Seneci
  • Publisher : Academic Press
  • Release Date : 2014-10-07
  • Total pages : 314
  • ISBN : 9780128019443
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Summary : Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical ...

Quality Control of Cellular Protein in Neurodegenerative Disorders

Quality Control of Cellular Protein in Neurodegenerative Disorders
  • Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
  • Publisher : IGI Global
  • Release Date : 2020-02-14
  • Total pages : 515
  • ISBN : 9780128019443
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Summary : Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of ...

Chemical Biology of Neurodegeneration

Chemical Biology of Neurodegeneration
  • Author : Pedro Merino
  • Publisher : John Wiley & Sons
  • Release Date : 2019-08-07
  • Total pages : 384
  • ISBN : 9780128019443
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Summary : Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on ...

Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Release Date : 2018-06-05
  • Total pages : 194
  • ISBN : 9780128019443
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Summary : Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways ...

Neurodegenerative Diseases New Insights for the Healthcare Professional 2013 Edition

Neurodegenerative Diseases  New Insights for the Healthcare Professional  2013 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-07-22
  • Total pages : 338
  • ISBN : 9780128019443
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Summary : Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ...

Proteostasis and Chaperone Surveillance

Proteostasis and Chaperone Surveillance
  • Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar,Parvaiz Ahmad
  • Publisher : Springer
  • Release Date : 2015-11-26
  • Total pages : 180
  • ISBN : 9780128019443
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Summary : Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, ...

Ubiquitination in Health and Diseases

Ubiquitination in Health and Diseases
  • Author : Tomoaki Ishigami
  • Publisher : MDPI
  • Release Date : 2021-05-18
  • Total pages : 292
  • ISBN : 9780128019443
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Summary : Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which ...

Protein Misfolding in Neurodegenerative Diseases

Protein Misfolding in Neurodegenerative Diseases
  • Author : Robert D. E. Sewell
  • Publisher : CRC Press
  • Release Date : 2007-12-03
  • Total pages : 592
  • ISBN : 9780128019443
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Summary : Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet ...

Chemical Tools for Imaging Manipulating and Tracking Biological Systems Diverse Methods for Optical Imaging and Conjugation

Chemical Tools for Imaging  Manipulating  and Tracking Biological Systems  Diverse Methods for Optical Imaging and Conjugation
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-05-29
  • Total pages : 430
  • ISBN : 9780128019443
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Summary : Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Optical Imaging and Conjugation, Volume 639, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Fluorogenic detection ...

Protein Misfolding

Protein Misfolding
  • Author : Rossen Donev
  • Publisher : Academic Press
  • Release Date : 2020-01-13
  • Total pages : 450
  • ISBN : 9780128019443
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Summary : Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein ...

Using Old Solutions to New Problems

Using Old Solutions to New Problems
  • Author : Marianna Kulka
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-06-19
  • Total pages : 426
  • ISBN : 9780128019443
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Summary : The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a ...

Advances in Molecular Toxicology

Advances in Molecular Toxicology
  • Author : James C. Fishbein,Jacqueline M. Heilman
  • Publisher : Academic Press
  • Release Date : 2019-10-12
  • Total pages : 164
  • ISBN : 9780128019443
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Summary : Advances in Molecular Toxicology, Volume Thirteen, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest ...

Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases

Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
  • Author : Yu Tang,Isidre Ferrer
  • Publisher : Frontiers Media SA
  • Release Date : 2022-08-15
  • Total pages : 212
  • ISBN : 9780128019443
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Summary : Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise ...