Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

• Author : Pierfausto Seneci
• Publisher : Academic Press
• Release Date : 2015-01-12
• Total pages : 260
• ISBN : 9780128019443

GET BOOK

Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

• Author : Pierfausto Seneci
• Publisher : Academic Press
• Release Date : 2015-01-14
• Total pages : 260
• ISBN : 9780128019443

GET BOOK

Summary : This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The ...

• Author : Pierfausto Seneci
• Publisher : Academic Press
• Release Date : 2014-10-07
• Total pages : 314
• ISBN : 9780128019443

GET BOOK

Summary : Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical ...

• Author : Uddin, Md. Sahab,Ashraf, Ghulam Md.
• Publisher : IGI Global
• Release Date : 2020-02-14
• Total pages : 515
• ISBN : 9780128019443

GET BOOK

Summary : Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of ...

• Author : Pedro Merino
• Publisher : John Wiley & Sons
• Release Date : 2019-08-07
• Total pages : 384
• ISBN : 9780128019443

GET BOOK

Summary : Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on ...

• Author : Pierfausto Seneci
• Publisher : Elsevier
• Release Date : 2018-06-05
• Total pages : 194
• ISBN : 9780128019443

GET BOOK

Summary : Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways ...

• Author : Anonim
• Publisher : ScholarlyEditions
• Release Date : 2013-07-22
• Total pages : 338
• ISBN : 9780128019443

GET BOOK

Summary : Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Neurodegenerative Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ...

• Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar,Parvaiz Ahmad
• Publisher : Springer
• Release Date : 2015-11-26
• Total pages : 180
• ISBN : 9780128019443

GET BOOK

Summary : Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, ...

• Author : Tomoaki Ishigami
• Publisher : MDPI
• Release Date : 2021-05-18
• Total pages : 292
• ISBN : 9780128019443

GET BOOK

Summary : Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which ...

• Author : Robert D. E. Sewell
• Publisher : CRC Press
• Release Date : 2007-12-03
• Total pages : 592
• ISBN : 9780128019443

GET BOOK

Summary : Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet ...

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2020-05-29
• Total pages : 430
• ISBN : 9780128019443

GET BOOK

Summary : Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Optical Imaging and Conjugation, Volume 639, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Fluorogenic detection ...

• Author : Rossen Donev
• Publisher : Academic Press
• Release Date : 2020-01-13
• Total pages : 450
• ISBN : 9780128019443

GET BOOK

Summary : Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein ...

• Author : Marianna Kulka
• Publisher : BoD – Books on Demand
• Release Date : 2013-06-19
• Total pages : 426
• ISBN : 9780128019443

GET BOOK

Summary : The medicinal use of plants, animals and microorganisms has been a part of human evolution and likely began before recorded history. Is it possible that this knowledge can be used to create powerful new drugs and solve some of the human health problems facing us today? This book is a ...

• Author : James C. Fishbein,Jacqueline M. Heilman
• Publisher : Academic Press
• Release Date : 2019-10-12
• Total pages : 164
• ISBN : 9780128019443

GET BOOK

Summary : Advances in Molecular Toxicology, Volume Thirteen, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest ...

• Author : Yu Tang,Isidre Ferrer
• Publisher : Frontiers Media SA
• Release Date : 2022-08-15
• Total pages : 212
• ISBN : 9780128019443

GET BOOK

Summary : Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise ...