Cancer Genomics

Written By Robert L. Strausberg
Cancer Genomics
  • Publsiher : IOS Press
  • Release : 03 October 2022
  • ISBN : 9781586032517
  • Pages : 92 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Cancer Genomics written by Robert L. Strausberg which was release on 03 October 2022, this book published by IOS Press. Available in PDF, EPUB and Kindle Format. Book excerpt: This work states that we are no longer satisfied to study a gene or gene product in isolation, but rather we strive to view each gene within the complex circuitry of a cell. It states that as a family of diseases, all cancer results from changes in the genome.

Cancer Genomics

Cancer Genomics
  • Author : Robert L. Strausberg
  • Publisher : IOS Press
  • Release Date : 2002
  • Total pages : 92
  • ISBN : 9781586032517
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Summary : This work states that we are no longer satisfied to study a gene or gene product in isolation, but rather we strive to view each gene within the complex circuitry of a cell. It states that as a family of diseases, all cancer results from changes in the genome....

Cancer Genomics

Cancer Genomics
  • Author : Graham Dellaire,Jason N Berman,Robert J. Arceci
  • Publisher : Academic Press
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these ...

Cancer Genomics

Cancer Genomics
  • Author : Moamen Bydoun,Paola Marcato,Graham Dellaire
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Breast cancer is the most common cancer in women worldwide and the second leading cause of cancer deaths. Although early diagnosis, outcome prediction and treatment options are the ultimate objectives when assessing breast cancer patients, the methodology behind this clinical assessment varies and has gradually evolved from using standard clinical ...

Cancer Genomics

Cancer Genomics
  • Author : Katayoon Kasaian,Yvonne Y. Li,Steven J.M. Jones
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Advances in high-throughput sequencing technologies have enabled cost-effective sequencing of a single human genome at an unprecedented rate, facilitating scientific endeavours never imagined possible before. These improvements have transformed the field of cancer genomics, allowing the complete molecular characterization of individual cancer genomes. However, the promise of unveiling the complexity ...

Cancer Genomics

Cancer Genomics
  • Author : Michael Fraser,Alejandro Berlin,Veronique Ouellet,Fred Saad,Robert G. Bristow
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Prostate cancer (CaP) is the most commonly diagnosed malignancy in men in the Western world. In North America, more than 275000 men are diagnosed annually whereby approximately 1 in 6 men will be diagnosed with CaP in their lifetime, and 1 in 34 men will die from castrate-resistant metastatic disease. Unfortunately, current clinical prognostic factors ...

Cancer Genomics

Cancer Genomics
  • Author : Hye-Jung E. Chun,Jaswinder Khattra,Martin Krzywinski,Samuel A. Aparicio,Marco A. Marra
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Cancer results from accumulated mutations in the genome. Sequencing is an accurate method to detect mutations. Second-generation sequencing technology, commonly referred to as next-generation sequencing technology, enables rapid, efficient and affordable DNA sequencing, and is transforming the scale and scope of cancer research. The technology is sufficiently flexible and affordable ...

Cancer Genomics

Cancer Genomics
  • Author : Ulrich Pfeffer
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-02-12
  • Total pages : 588
  • ISBN : 9781586032517
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Summary : The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It ...

Cancer Genomics

Cancer Genomics
  • Author : Matthew Parker,Erin Hedlund,Jinghui Zhang
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : The vast amount of genomic data being produced by the research community is becoming readily accessible to biomedical researchers and clinicians to apply to their cancer(s) of interest. The major cancer genome projects, among others, The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC) and the Pediatric ...

Cancer Genomics

Cancer Genomics
  • Author : Shile Zhang,Jun S. Wei,Javed Khan
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : The complexity of the transcriptome has been appreciated in recent years in light of the Encyclopedia of DNA Elements (ENCODE) project. While less than 3% of the genome is annotated with protein-coding genes, 62% of the genome is long RNA molecules (>200 nucleotides). With an increasing sequencing throughput and a decreasing cost, RNA ...

Cancer Genomics

Cancer Genomics
  • Author : Jason N. Berman,Priscilla P.L. Chiu,Graham Dellaire
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Genome-wide association (GWA) studies and tumor-specific epigenome, transcriptome and genome sequencing projects are generating an ever-growing list of susceptibility alleles, as well as putative gain- and loss-of-function gene mutations associated with cancer. These genetic changes ultimately need to be validated to determine their contribution to the initiation, progression and likelihood ...

Cancer Genomics

Cancer Genomics
  • Author : Louise Parker
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : The number of people diagnosed with cancer each year will almost double to 21 million cases worldwide by 2030 because of the aging population. Studies of the human genome have demonstrated that as few as 5–10% of adult cancers are due to genetic inheritance. Over 90% of cancers are due to endogenous or exogenous ...

Cancer Genomics

Cancer Genomics
  • Author : Daniel Gaston,Carman Giacomantonio
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Colorectal cancer (CRC) is the third most common form of cancer and a leading cause of cancer-related mortality in both men and women, particularly in Western and developed nations. The high mortality rate has been attributed to the fact that colon cancer is often diagnosed at a late stage. Three ...

Cancer Genomics

Cancer Genomics
  • Author : Branavan Manoranjan,Parvez Vora,Chitra Venugopal,Sheila K. Singh
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : The classification of brain tumors has evolved from a morphological and histological basis to one that is now in keeping with the advances of modern technology consisting of novel molecular subgroups rooted in clinical outcome and risk stratification. In this chapter, we discuss recent and emerging genomic findings that may ...

Cancer Genomics

Cancer Genomics
  • Author : Ryan D. Morin,Stephen B. Montgomery
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Identifying gene expression changes in cancer provides opportunities to identify biomarkers that can be informative in regard to risk and in the choice of treatment options. In recent years, advances in sequencing have provided not only a quantitative measure of gene expression, but the resolution of diverse species of RNA, ...

Cancer Genomics

Cancer Genomics
  • Author : Matthew Herder,Conrad V Fernandez
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 9781586032517
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Summary : Large-scale cancer genomics research projects raise a range of ethical and legal issues. We focus on two emerging themes challenged within genomic research: (1) issues surrounding the return of research results to research participants, whether in summary or individualized form, and (2) issues connected to the commercialization of research, including the patenting ...