Antibody Fc

Written By Peter Sun
Antibody Fc
  • Publsiher : Elsevier Inc. Chapters
  • Release : 06 August 2013
  • ISBN : 012806028X
  • Pages : 358 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Antibody Fc written by Peter Sun which was release on 06 August 2013, this book published by Elsevier Inc. Chapters. Available in PDF, EPUB and Kindle Format. Book excerpt: Molecular mechanisms of antibody-mediated Fc receptor activation have long been an interest in both Fc receptor biology and antibody therapeutics. The structural efforts to elucidate antibody recognition by Fc receptors have led to the generation of several crystal structures of antibody Fc fragments complexed with Fc receptors. Collectively, these structures revealed a conserved receptor binding mode for IgG and IgE, distinct from those for the neonatal Fc receptor (FcRn), protein A, and protein G. Fcγ receptor recognition in the lower hinge region allows enhanced antigen recognition through dimeric Fabs but obligates immune-complex formation for receptor activation. It also provides the basis for Fcγ receptors to differentiate among IgG subclasses. More recently, pentraxins have also been shown to bind and activate Fc receptors, and structural efforts to elucidate pentraxin Fcγ receptor recognition have revealed surprising similarities between pentraxins and immunoglobulins in Fc receptor recognition. This review summarizes the structural findings that formed the basis of modern antibody–Fc receptor biology and recent advances of shared Fc receptor recognition by innate pentraxins.

Antibody Fc

Antibody Fc
  • Author : Margaret Ackerman,Falk Nimmerjahn
  • Publisher : Academic Press
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume ...

Antibody Fc

Antibody Fc
  • Author : Victor Raúl Gómez Román,Joseph C. Murray,Louis M. Weiner
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : Antibody-dependent cellular cytotoxicity (ADCC), also called antibody-dependent cell-mediated cytotoxicity, is an immune mechanism through which Fc receptor-bearing effector cells can recognize and kill antibody-coated target cells expressing tumor- or pathogen-derived antigens on their surface. Numerous associations between ADCC activity, Fc receptor polymorphisms, and clinical outcomes have been observed in both ...

Fc Mediated Antibody Functions and Fc Receptor Polymorphism

Fc Mediated Antibody Functions and Fc Receptor Polymorphism
  • Author : Guido Ferrari,Georgia Tomaras,R. Keith Reeves,Gabriella Scarlatti
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-28
  • Total pages : 212
  • ISBN : 012806028X
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Summary : Download or read online Fc Mediated Antibody Functions and Fc Receptor Polymorphism written by Guido Ferrari,Georgia Tomaras,R. Keith Reeves,Gabriella Scarlatti, published by Frontiers Media SA which was released on 2020-07-28. Get Fc Mediated Antibody Functions and Fc Receptor Polymorphism Books now! Available in PDF, ePub and ...

Antibody Fc

Antibody Fc
  • Author : Peter Sun
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : Molecular mechanisms of antibody-mediated Fc receptor activation have long been an interest in both Fc receptor biology and antibody therapeutics. The structural efforts to elucidate antibody recognition by Fc receptors have led to the generation of several crystal structures of antibody Fc fragments complexed with Fc receptors. Collectively, these structures ...

Antibody Fc

Antibody Fc
  • Author : Theo Rispens,Gestur Vidarsson
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : Immunoglobulins are a group of closely related glycoproteins composed of 82 to 96% protein and 4 to 18% carbohydrate. In humans, there are five classes of immunoglobulins, which differ in heavy-chain structure. Immunoglobulin G (IgG) is the major class of immunoglobulins in blood and can be further subdivided in subclasses. The four subclasses of ...

Antibody Fc

Antibody Fc
  • Author : Roy Jefferis
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : Diversity of antigen-binding specificity may be considered the hallmark of antibodies; however, the human IgG-Fc region also exhibits binding specificity for multiple ligands. Evolution of the IgG-Fc has resulted in the generation of interaction sites for endogenous (self) ligands that recruit and activate mechanisms facilitating the removal and destruction of ...

Antibody Fc

Antibody Fc
  • Author : Xiaojie Yu,Kavitha Baruah,Christopher N. Scanlan,Max Crispin
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : The antibody Fc region is posttranslationally modified by N-linked glycosylation. In immunoglobulin G (IgG), the processing of the glycans is restricted by the presence of extensive interaction with the protein surface. The resulting set of antibody glycoforms exhibit a range of effector functions. In this chapter, we outline the impact ...

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : William R Strohl,Lila M Strohl
  • Publisher : Elsevier
  • Release Date : 2012-10-16
  • Total pages : 696
  • ISBN : 012806028X
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Summary : The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that ...

Antibody Engineering Volume 2

Antibody Engineering Volume 2
  • Author : Roland E. Kontermann,Stefan Dübel
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-10
  • Total pages : 589
  • ISBN : 012806028X
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Summary : Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The ...

Antibody Fc

Antibody Fc
  • Author : Marije B. Overdijk,Sandra Verploegen,Wim K. Bleeker,Paul W.H.I. Parren
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : Historically, lack of specificity for cancer cells has been a major problem in cancer treatment; however, the development of monoclonal antibodies (mAbs), which combine high specificity with multiple mechanisms of action (MoAs), started a revolution in anti-cancer treatment options which continues to date. As of January 2013, 15 major antibody products were ...

Antibody Engineering Volume 1

Antibody Engineering Volume 1
  • Author : Roland E. Kontermann,Stefan Dübel
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-10
  • Total pages : 788
  • ISBN : 012806028X
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Summary : Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The ...

Antibody Fc Engineering Towards Better Therapeutics

Antibody Fc Engineering  Towards Better Therapeutics
  • Author : Tianlei Ying,Rui Gong
  • Publisher : Frontiers Media SA
  • Release Date : 2018-12-21
  • Total pages : 212
  • ISBN : 012806028X
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Summary : Download or read online Antibody Fc Engineering Towards Better Therapeutics written by Tianlei Ying,Rui Gong, published by Frontiers Media SA which was released on 2018-12-21. Get Antibody Fc Engineering Towards Better Therapeutics Books now! Available in PDF, ePub and Kindle....

Antibody Fc

Antibody Fc
  • Author : Robert M. Anthony
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 012806028X
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Summary : IgG antibodies are highly potent molecules, with the unique ability to link foreign particles to innate immune cells. IgG antibodies recognize antigens with high affinity and bind cellular Fc receptors with low affinity individually. These interactions occur in the form of immune complexes, resulting in high-avidity interactions. In fact, the ...

Monoclonal Antibodies

Monoclonal Antibodies
  • Author : Maher Albitar
  • Publisher : Springer Science & Business Media
  • Release Date : 2007
  • Total pages : 228
  • ISBN : 012806028X
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Summary : Monoclonal Antibodies: Methods and Protocols examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting with opening chapters focusing on the gold standard method for generating mouse monoclonal antibodies through hybridoma technology, future methods for engineering recombinant and humanized antibodies, methods for engineering soluble Fc fusion ...

Antibody Drug Discovery

Antibody Drug Discovery
  • Author : Clive R. Wood
  • Publisher : World Scientific
  • Release Date : 2012
  • Total pages : 473
  • ISBN : 012806028X
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Summary : Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned ...