Animal Models in Cancer Drug Discovery

Written By Asfar Azmi
Animal Models in Cancer Drug Discovery
  • Publsiher : Academic Press
  • Release : 16 April 2019
  • ISBN : 0128147059
  • Pages : 470 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKAnimal Models in Cancer Drug Discovery


Read or download book entitled Animal Models in Cancer Drug Discovery written by Asfar Azmi which was release on 16 April 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release Date : 2019-04-16
  • Total pages : 470
  • ISBN : 0128147059
GET BOOK

Summary : Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on ...

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • Total pages : 594
  • ISBN : 0128147059
GET BOOK

Summary : This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on ...

Animal Models for Human Cancer

Animal Models for Human Cancer
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger
  • Publisher : John Wiley & Sons
  • Release Date : 2016-05-18
  • Total pages : 272
  • ISBN : 0128147059
GET BOOK

Summary : Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the ...

Translational Animal Models in Drug Discovery and Development

Translational Animal Models in Drug Discovery and Development
  • Author : Xinkang Wang
  • Publisher : Bentham Science Publishers
  • Release Date : 2012-10-03
  • Total pages : 287
  • ISBN : 0128147059
GET BOOK

Summary : Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene ...

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-01
  • Total pages : 693
  • ISBN : 0128147059
GET BOOK

Summary : The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the ...

Camptothecins in Cancer Therapy

Camptothecins in Cancer Therapy
  • Author : Val R. Adams
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-10-27
  • Total pages : 460
  • ISBN : 0128147059
GET BOOK

Summary : A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known ...

Drug Discovery in Pancreatic Cancer

Drug Discovery in Pancreatic Cancer
  • Author : Haiyong Han,Paul Grippo
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-11
  • Total pages : 297
  • ISBN : 0128147059
GET BOOK

Summary : Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with advanced pancreatic cancer is about 6-months. This dismal ...

Cytokines in the Genesis and Treatment of Cancer

Cytokines in the Genesis and Treatment of Cancer
  • Author : Michael A. Caligiuri,Michael T. Lotze
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-09-19
  • Total pages : 482
  • ISBN : 0128147059
GET BOOK

Summary : Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. The book brings together an impressive array of internationally ...

What Will We Do If We Don t Experiment on Animals

What Will We Do If We Don t Experiment on Animals
  • Author : Jean Swingle Greek,C. Ray Greek
  • Publisher : Trafford Publishing
  • Release Date : 2004
  • Total pages : 261
  • ISBN : 0128147059
GET BOOK

Summary : Drs. Greek have written 2 books on why using animals as models for humans is not the best way to conduct medical research and drug testing. During their lectures and debates, the most commonly asked question was, "Well. What will we use if we don't use animals?" What Will We Do ...

COX 2 Blockade in Cancer Prevention and Therapy

COX 2 Blockade in Cancer Prevention and Therapy
  • Author : Randall E. Harris
  • Publisher : Springer Science & Business Media
  • Release Date : 2002-10-03
  • Total pages : 371
  • ISBN : 0128147059
GET BOOK

Summary : The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly ...

Molecular Cancer Therapeutics

Molecular Cancer Therapeutics
  • Author : George C. Prendergast
  • Publisher : John Wiley & Sons
  • Release Date : 2004-04-02
  • Total pages : 368
  • ISBN : 0128147059
GET BOOK

Summary : Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters ...

Tumor Suppressor Genes in Human Cancer

Tumor Suppressor Genes in Human Cancer
  • Author : David E. Fisher
  • Publisher : Springer Science & Business Media
  • Release Date : 2000-10-26
  • Total pages : 386
  • ISBN : 0128147059
GET BOOK

Summary : David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell ...

Drug Discovery from Mother Nature

Drug Discovery from Mother Nature
  • Author : Subash Chandra Gupta,Sahdeo Prasad,Bharat B. Aggarwal
  • Publisher : Springer
  • Release Date : 2016-10-22
  • Total pages : 410
  • ISBN : 0128147059
GET BOOK

Summary : Second comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in prevention and therapy of various chronic diseases. Food and drug administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with ...

Animal Models for Human Cancer Volume 69

Animal Models for Human Cancer  Volume 69
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-08-15
  • Total pages : 272
  • ISBN : 0128147059
GET BOOK

Summary : Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the ...

Mouse Models for Drug Discovery

Mouse Models for Drug Discovery
  • Author : Gabriele Proetzel,Michael V. Wiles
  • Publisher : Humana
  • Release Date : 2016-08-23
  • Total pages : 421
  • ISBN : 0128147059
GET BOOK

Summary : As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse ...