AGO Driven Non Coding RNAs

Written By Bibekanand Mallick
AGO Driven Non Coding RNAs
  • Publsiher : Academic Press
  • Release : 20 January 2019
  • ISBN : 0128156708
  • Pages : 387 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKAGO Driven Non Coding RNAs


Read or download book entitled AGO Driven Non Coding RNAs written by Bibekanand Mallick which was release on 20 January 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

AGO Driven Non Coding RNAs

AGO Driven Non Coding RNAs
  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Total pages : 387
  • ISBN : 0128156708
GET BOOK

Summary : The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily ...

Clinical Applications of Noncoding RNAs in Cancer

Clinical Applications of Noncoding RNAs in Cancer
  • Author : Subash Gupta,Kishore Challagundla
  • Publisher : Academic Press
  • Release Date : 2022-01-28
  • Total pages : 478
  • ISBN : 0128156708
GET BOOK

Summary : Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides ...

Essentials of Cancer Genomic Computational Approaches and Precision Medicine

 Essentials of Cancer Genomic  Computational Approaches and Precision Medicine
  • Author : Nosheen Masood,Saima Shakil Malik
  • Publisher : Springer Nature
  • Release Date : 2020-03-20
  • Total pages : 499
  • ISBN : 0128156708
GET BOOK

Summary : This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent ...

Non coding RNAs and Cancer

Non coding RNAs and Cancer
  • Author : Muller Fabbri
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-28
  • Total pages : 284
  • ISBN : 0128156708
GET BOOK

Summary : The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of ...

Long Non Coding RNAs and Immunity

Long Non Coding RNAs and Immunity
  • Author : Adam Williams,Jorge Henao-Mejia
  • Publisher : Frontiers Media SA
  • Release Date : 2021-06-29
  • Total pages : 212
  • ISBN : 0128156708
GET BOOK

Summary : We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased ...

Omics Technologies for Sustainable Agriculture and Global Food Security Vol II

Omics Technologies for Sustainable Agriculture and Global Food Security  Vol II
  • Author : Anirudh Kumar,Rakesh Kumar,Pawan Shukla,Hitendra K. Patel
  • Publisher : Springer Nature
  • Release Date : 2021-08-05
  • Total pages : 351
  • ISBN : 0128156708
GET BOOK

Summary : This edited book brings out a comprehensive collection of information on the modern omics-based research. The main focus of this book is to educate researchers about utility of omics-based technologies in rapid crop improvement. In last two decades, omics technologies have been utilized significantly in the area of plant sciences ...

Regulation by non coding RNAs Volume 1

Regulation by non coding RNAs Volume 1
  • Author : Nicholas Delihas
  • Publisher : MDPI
  • Release Date : 2018-10-09
  • Total pages : 850
  • ISBN : 0128156708
GET BOOK

Summary : Printed Edition of the Special Issue Published in IJMS...

Long Non coding RNAs in Human Disease

Long Non coding RNAs in Human Disease
  • Author : Kevin V. Morris
  • Publisher : Springer
  • Release Date : 2016-04-13
  • Total pages : 262
  • ISBN : 0128156708
GET BOOK

Summary : This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play ...

Cancer and Noncoding RNAs

Cancer and Noncoding RNAs
  • Author : Jayprokas Chakrabarti,Sanga Mitra
  • Publisher : Academic Press
  • Release Date : 2017-10-13
  • Total pages : 576
  • ISBN : 0128156708
GET BOOK

Summary : Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and ...

The Long and Short Non coding RNAs in Cancer Biology

The Long and Short Non coding RNAs in Cancer Biology
  • Author : Erwei Song
  • Publisher : Springer
  • Release Date : 2016-07-04
  • Total pages : 458
  • ISBN : 0128156708
GET BOOK

Summary : The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in ...

Non coding RNA and the Reproductive System

Non coding RNA and the Reproductive System
  • Author : Dagmar Wilhelm,Pascal Bernard
  • Publisher : Springer
  • Release Date : 2015-12-11
  • Total pages : 198
  • ISBN : 0128156708
GET BOOK

Summary : This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, ...

The Orchid Genome

The Orchid Genome
  • Author : Fure-Chyi Chen,Shih-Wen Chin
  • Publisher : Springer Nature
  • Release Date : 2021
  • Total pages : 162
  • ISBN : 0128156708
GET BOOK

Summary : This book provides information on genome complexity and evolution, transcriptome analysis, miRNome, simple sequence repeats, genome relationships, molecular cytogenetics, polyploidy induction and application, flower and embryo development. Orchids account for a great part of the worldwide floriculture trade both as cut flowers and as potted plants and are assessed to ...

Regulation of Soluble Immune Mediators by Non Coding RNAs

Regulation of Soluble Immune Mediators by Non Coding RNAs
  • Author : Flavia Bazzoni,Daniela Bosisio
  • Publisher : Frontiers Media SA
  • Release Date : 2020-12-11
  • Total pages : 212
  • ISBN : 0128156708
GET BOOK

Summary : Download or read online Regulation of Soluble Immune Mediators by Non Coding RNAs written by Flavia Bazzoni,Daniela Bosisio, published by Frontiers Media SA which was released on 2020-12-11. Get Regulation of Soluble Immune Mediators by Non Coding RNAs Books now! Available in PDF, ePub and Kindle....

The Role of ncRNA in Cardiac Remodeling

The Role of ncRNA in Cardiac Remodeling
  • Author : Zhanpeng Huang,Kun Wang,Jiandong Liu
  • Publisher : Frontiers Media SA
  • Release Date : 2022-04-20
  • Total pages : 212
  • ISBN : 0128156708
GET BOOK

Summary : Download or read online The Role of ncRNA in Cardiac Remodeling written by Zhanpeng Huang,Kun Wang,Jiandong Liu, published by Frontiers Media SA which was released on 2022-04-20. Get The Role of ncRNA in Cardiac Remodeling Books now! Available in PDF, ePub and Kindle....

Non coding RNAs in Colorectal Cancer

Non coding RNAs in Colorectal Cancer
  • Author : Ondrej Slaby,George A. Calin
  • Publisher : Springer
  • Release Date : 2016-08-29
  • Total pages : 252
  • ISBN : 0128156708
GET BOOK

Summary : This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of ...