Adverse Events and Oncotargeted Kinase Inhibitors

Written By Giuseppe Tridente
Adverse Events and Oncotargeted Kinase Inhibitors
  • Publsiher : Academic Press
  • Release : 08 May 2017
  • ISBN : 0128094451
  • Pages : 736 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Adverse Events and Oncotargeted Kinase Inhibitors written by Giuseppe Tridente which was release on 08 May 2017, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events. Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more

Adverse Events and Oncotargeted Kinase Inhibitors

Adverse Events and Oncotargeted Kinase Inhibitors
  • Author : Giuseppe Tridente
  • Publisher : Academic Press
  • Release Date : 2017-05-08
  • Total pages : 736
  • ISBN : 0128094451
GET BOOK

Summary : Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring ...

Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy

Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy
  • Author : Salem Chouaib,James Lorens
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-02
  • Total pages : 212
  • ISBN : 0128094451
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Summary : Download or read online Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy written by Salem Chouaib,James Lorens, published by Frontiers Media SA which was released on 2020-07-02. Get Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy Books now! Available in ...

Immunotherapy for Gastrointestinal Malignancies

Immunotherapy for Gastrointestinal Malignancies
  • Author : Ramakrishna Vadde,Ganji Purnachandra Nagaraju
  • Publisher : Springer Nature
  • Release Date : 2021-01-31
  • Total pages : 251
  • ISBN : 0128094451
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Summary : This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews ...

Targeted Therapies for Lung Cancer

Targeted Therapies for Lung Cancer
  • Author : Ravi Salgia
  • Publisher : Springer
  • Release Date : 2019-06-26
  • Total pages : 238
  • ISBN : 0128094451
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Summary : This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights ...

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-11-21
  • Total pages : 292
  • ISBN : 0128094451
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Summary : Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have ...

Side Effects of Drugs Annual

Side Effects of Drugs Annual
  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2017-10-19
  • Total pages : 582
  • ISBN : 0128094451
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Summary : Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 39 presents the latest on a variety of topics, with new chapters in this volume covering Central nervous system stimulants and drugs that suppress appetite, Antidepressant drugs, Lithium, Drugs of abuse, Hypnotics and sedatives, ...

Protein Kinases

Protein Kinases
  • Author : Anonim
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-12-08
  • Total pages : 162
  • ISBN : 0128094451
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Summary : For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways ...

Role of Tyrosine Kinases in Gastrointestinal Malignancies

Role of Tyrosine Kinases in Gastrointestinal Malignancies
  • Author : Ganji Purnachandra Nagaraju
  • Publisher : Springer
  • Release Date : 2018-09-27
  • Total pages : 241
  • ISBN : 0128094451
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Summary : The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to ...

Evidence based Advance and Management of Adverse Events of Immunotherapy for Cancer

Evidence based Advance and Management of Adverse Events of Immunotherapy for Cancer
  • Author : Yonggang Zhang,Xuelei Ma,Shuang Zhou
  • Publisher : Frontiers Media SA
  • Release Date : 2020-12-22
  • Total pages : 212
  • ISBN : 0128094451
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Summary : Download or read online Evidence based Advance and Management of Adverse Events of Immunotherapy for Cancer written by Yonggang Zhang,Xuelei Ma,Shuang Zhou, published by Frontiers Media SA which was released on 2020-12-22. Get Evidence based Advance and Management of Adverse Events of Immunotherapy for Cancer Books now! ...

An Innovative Approach to Understanding and Treating Cancer Targeting pH

An Innovative Approach to Understanding and Treating Cancer  Targeting pH
  • Author : Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey
  • Publisher : Academic Press
  • Release Date : 2020-01-16
  • Total pages : 574
  • ISBN : 0128094451
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Summary : An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of ...

Infections Related to Biologics An Issue of Infectious Disease Clinics of North America

Infections Related to Biologics An Issue of Infectious Disease Clinics of North America
  • Author : Aruna K. Subramanian,Dora Ho
  • Publisher : Elsevier Health Sciences
  • Release Date : 2020-06-04
  • Total pages : 240
  • ISBN : 0128094451
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Summary : In collaboration with Consulting Editor Dr. Helen Boucher, Drs. Aruna Subramanian and Dora Yuk-Wai Ho have created an extremely timely and relevant issue for infectious disease physcians, as the field of biologics is exploding. These new agents are being used in rheumatologic diseases, hematologic malignancies, solid tumors, and other conditions; ...

Anticancer Agents

Anticancer Agents
  • Author : Qiao-Hong Chen
  • Publisher : MDPI
  • Release Date : 2021-03-02
  • Total pages : 606
  • ISBN : 0128094451
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Summary : This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for ...

Small Molecules in Hematology

Small Molecules in Hematology
  • Author : Uwe M. Martens
  • Publisher : Springer
  • Release Date : 2018-08-01
  • Total pages : 294
  • ISBN : 0128094451
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Summary : This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each ...

Renal Pharmacotherapy

Renal Pharmacotherapy
  • Author : Larry K. Golightly,Isaac Teitelbaum,Bonita A. Simendinger,Tyree H. Kiser,Gerard R. Barber,Nancy M. Stolpman
  • Publisher : Springer Nature
  • Release Date : 2021
  • Total pages : 829
  • ISBN : 0128094451
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Summary : To promote effectiveness and minimize possible toxicity, the dosage of certain medications must be adjusted in persons with compromised kidney function. Failure to enjoin appropriate dosage adjustments in patients with abnormal or rapidly changing kidney function continues to lead to reports of drug toxicity involving a broad array of renally ...

Triple negative Breast Cancer

Triple negative Breast Cancer
  • Author : Xiyun Deng,Faqing Tang,Thomas J Rosol
  • Publisher : World Scientific
  • Release Date : 2020-10-29
  • Total pages : 248
  • ISBN : 0128094451
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Summary : Triple-negative breast cancer (TNBC) represents a challenge clinically due to the lack of actionable targets coupled with an aggressive disease course and a worse prognosis compared to other breast cancer subtypes. This book covers aspects of TNBC ranging from epidemiology, biology, molecular classification, to currently available and potentially new therapeutic ...